DOIAbstract
The term atopic, which means “strange disease,” was first used in 1925 to describe a group of diseases which include allergic rhinitis, bronchial asthma, urticarial reactions to drugs as well as food allergies or idiosyncrasies. These conditions have in common the presence of skin sensitizing homocytotropic antibodies (IgE) in the serum of the person at some point in the natural history of the disease. There is little evidence that dermatitis found in the atopic individual is produced by IgE which is present in the serum and skin of the person with atopic dermatitis
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