Background Spinal central sensitization is an important process in the generation and maintenance of visceral hypersensitivity. The release of brain-derived neurotrophic factor (BDNF) from the primary afferent neurons to the spinal cord contributes to spinal neuronal plasticity and increases neuronal activity and synaptic efficacy. The N-Methyl-D-aspartic acid (NMDA) receptor possesses ion channel properties, and its activity is modulated by phosphorylation of its subunits including the NMDA receptor 1 (NR1). Methods Colonic inflammation was induced by a single dose of intracolonic instillation of tri-nitrobenzene sulfonic acid (TNBS). NR1 phosphorylation by BDNF in vivo and in culture was examined by western blot and immunohistochemistry....
In previous studies, we have found that the Glu N2B-containing NMDA(NMDA-Glu N2B) receptors-mediated...
At least some neurotrophins may be powerful modulators of synapses, thereby influencing short- and l...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling ...
Abstract The role of brain-derived neurotrophic factor (BDNF) in sensory hypersensitivity has been s...
Abstract Background N-methyl-D-aspartic acid (NMDA) spinal cord receptors play an important role in ...
The pathogenic mechanisms underlying neuropathic pain still remain largely unknown. In this study, w...
Previously we have demonstrated that brain-derived neurotrophic factor (BDNF) contributes to spinal ...
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the out...
AbstractThe roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitiza...
The primary sensory neurons that respond to noxious stimulation and project to the spinal cord are k...
Peripheral nerve injury activates spinal microglia. This leads to enduring changes in the properties...
Background In humans, inflammation of either the urinary bladder or the distal colon often results i...
The neurotrophin brain-derived neurotrophic factor (BDNF) plays an essential role during development...
BACKGROUND:Chronic pain is an important medical problem affecting hundreds of millions of people wor...
AbstractChronic pain due to nerve injury is resistant to current analgesics. Animal models of neurop...
In previous studies, we have found that the Glu N2B-containing NMDA(NMDA-Glu N2B) receptors-mediated...
At least some neurotrophins may be powerful modulators of synapses, thereby influencing short- and l...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling ...
Abstract The role of brain-derived neurotrophic factor (BDNF) in sensory hypersensitivity has been s...
Abstract Background N-methyl-D-aspartic acid (NMDA) spinal cord receptors play an important role in ...
The pathogenic mechanisms underlying neuropathic pain still remain largely unknown. In this study, w...
Previously we have demonstrated that brain-derived neurotrophic factor (BDNF) contributes to spinal ...
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the out...
AbstractThe roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitiza...
The primary sensory neurons that respond to noxious stimulation and project to the spinal cord are k...
Peripheral nerve injury activates spinal microglia. This leads to enduring changes in the properties...
Background In humans, inflammation of either the urinary bladder or the distal colon often results i...
The neurotrophin brain-derived neurotrophic factor (BDNF) plays an essential role during development...
BACKGROUND:Chronic pain is an important medical problem affecting hundreds of millions of people wor...
AbstractChronic pain due to nerve injury is resistant to current analgesics. Animal models of neurop...
In previous studies, we have found that the Glu N2B-containing NMDA(NMDA-Glu N2B) receptors-mediated...
At least some neurotrophins may be powerful modulators of synapses, thereby influencing short- and l...
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling ...