Multisystem inflammatory syndrome in children (MIS-C)

Multisistemski upalni sindrom u djece povezan s COVID-19 je relativno novi klinički sindrom sličan Kawasakijevoj bolesti koji se javlja oko 2–6 tjedana nakon preboljele SARS-CoV-2 infekcije. Bolest karakterizira vrućica uz zahvaćanje više organa i organskih sustava (koža/sluznice, gastrointestinalni, kardiovaskularni...), a u laboratorijskim nalazima dominiraju povišeni upalni parametri. Nema specifičnog dijagnostičkog testa za potvrdu ove bolesti, već je to dijagnoza isključenja, a postavlja na temelju dijagnostičkih kriterija. Osnovu liječenja čini primjena intravenskih imunoglobulina i kortikosteroida uz simptomatske i suportivne mjere. Bolest je karakterizirana sklonošću izazivanja kardioloških komplikacija zbog čega je važno sustavno praćenje ovih bolesnika i nakon akutne bolesti.Multisystemic inflammatory syndrome in children associated with COVID-19 is a relatively new clinical syndrome similar to Kawasaki disease that occurs about 2–6 weeks after SARS-CoV-2 infection. The disease is characterized by fever and involvement of several organ systems (skin/mucous membranes, gastrointestinal, cardiovascular...) associated with elevated inflammatory parameters. There is no specific diagnostic test to confirm this disease, it is a diagnosis of exclusion, based on specific diagnostic criteria. The basis of treatment is the use of intravenous immunoglobulins and corticosteroids with symptomatic and supportive measures. The disease is characterized by tendency to cause cardiac complications, which is why it is important to systematically monitor these patients even after acute illness