Novel Mechanisms for Augmenting Diabetic Wound Healing
- Knobel, D.
- Crawford, J.L.
- Nguyen, P. D.
- Tutela, J.
- Thanik, V.D.
- Klein, Jean-Claude
- Eydlin, O.
- Cohen, O.
- Davidson, E.H.
- Levine, J.P.
DOIAbstract
This paper is an Abstracts for the Fifth Annual Academic Surgical Congress (The Association for Academic Surgery and Society of University Surgeons)International audienceImpaired diabetic wound healing is multi-factorial and incompletely understood. Reactive oxygen species (ROS) and p53, a master gene regulator, are upregulated in diabetic wounds. We have demonstrated improved diabetic wound healing through a novel topical p53 silencing system. We hypothesized that topical silencing of p53 improves diabetic wound healing through a decrease in ROS
Add to ORKG