Novel Synthesis of 3-(Phenyl) (Ethylamino) Methyl)-4-Hydroxy-2H-Chromen-2-one Derivatives Using Biogenic ZnO Nanoparticles and their Applications

Received: 29.11.2021. Revised: 15.01.2022. Accepted: 15.01.2022. Available online: 21.01.2022.The authors declare that there are no conflicts of interests regarding the publication of this work.The present work describes the novel synthesis of 3, 3-((phenyl) (ethylamino) methyl)-4-hydroxy-2H-chromen-2-one derivatives catalyzed by biogenic ZnO nanoparticles. The synthesized heterocyclic compounds were characterized by fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) and mass spectrometric techniques. Absorption, distribution, metabolism and excretion properties and various toxicities (ADMET) studies and in silico molecular docking studies were carried out for the synthesized compounds. The synthesized compounds were screened for their efficacy towards the antioxidant activity and were subjected to corrosion inhibition study towards the mild steel in acidic medium by weight loss method. Additionally, the recyclability of the employed catalyst was studied.The authors are thankful to the Chairman, Department of Chemistry, Kuvempu University Shankaraghatta for providing the laboratory facilities and to the University of Mysore and Saif Karnatak University, Dharwad for provid-ing spectra. One of the authors, Anjan Kumar G C thankful to the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for providing a Junior Research fellow-ship [09/908(0010)/2019-EMR-I]