Cell Delivery: Routing Nanomolar Protein Cargoes to Lipid Raft-Mediated/Caveolar Endocytosis through a Ganglioside GM1-Specific Recognition Tag (Adv. Sci. 4/2020)
- Imre, Norbert
- Hetényi, Anasztázia
- Szabó, Enikő
- Bodnár, Brigitta
- Szkalisity, Abel
- Gróf, Ilona
- Bocsik, Alexandra
- Deli, Mária A.
- Horvath, Peter
- Czibula, Ágnes
- Monostori, Éva
- Martinek, Tamás A.
DOIAbstract
In article number 1902621, Tamás A. Martinek and co-workers develop a pentapeptidic tag, which reads the glycan code of ganglioside GM1 and triggers lipid raft-mediated endocytosis, avoiding lysosomal entrapment. This carrier molecule can deliver macromolecular cargoes (e.g., IgG complexes) into live cells with the possibility to escape to the cytosol.Peer reviewe
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