We report the breast cancer stem cell (CSC) potency of two nickel(II)-3,4,7,8-tetramethyl-1,10-phenanthroline complexes, 1 and 3, containing the non-steroidal anti-inflammatory drugs (NSAIDs), naproxen and indomethacin, respectively. The nickel(II) complexes, 1 and 3 kill breast CSCs and bulk breast cancer cells in the micromolar range. Notably, 1 and 3 display comparable or better potency towards breast CSCs than salinomycin, an established CSC-active agent. The complexes, 1 and 3 also display significantly lower toxicity towards non-cancerous epithelial breast cells than breast CSCs or bulk breast cancer cells (up to 4.6-fold). Mechanistic studies suggest that 1 and 3 downregulate cyclooxygenase-2 (COX-2) in breast CSCs and kill breast CS...
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphi...
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphi...
The cancer stem cell (CSC) potency of a series of structurally analogous Group 10-azadiphosphine met...
We report the breast cancer stem cell (CSC) potency of two nickel(II)-3,4,7,8-tetramethyl-1,10-phena...
The anti-breast cancer stem cell (CSC) properties of a series of gold(i) complexes comprising variou...
The effect of a newly developed osmium(VI) nitrido complex, 1, on breast cancer stem cells (CSCs) is...
Cancer stem cells (CSCs) are thought of as a clinically pertinent subpopulation of tumors, partly re...
Immunogenic cell death (ICD) offers a method of stimulating the immune system to attack and remove c...
Copper(II) complexes bearing nonsteroidal anti-inflammatory drugs (NSAIDs) are known to potently kil...
Breast cancer stem cells (CSCs) are a sub-population of tumour cells that can promote breast cancer ...
The effect of a newly developed osmium(VI) nitrido complex, 1, on breast cancer stem cells (CSCs) is...
Intracellular redox modulation offers a viable approach to effectively remove cancer stem cells (CSC...
Cancer stem cells (CSCs) are thought to be responsible for cancer relapse. CSCs are a subtype of can...
The effect of a newly developed osmium(VI) nitrido complex, <b>1</b>, on breast cancer stem cells (C...
Cancer stem cells (CSCs) are thought to be responsible for cancer relapse. CSCs are a subtype of can...
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphi...
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphi...
The cancer stem cell (CSC) potency of a series of structurally analogous Group 10-azadiphosphine met...
We report the breast cancer stem cell (CSC) potency of two nickel(II)-3,4,7,8-tetramethyl-1,10-phena...
The anti-breast cancer stem cell (CSC) properties of a series of gold(i) complexes comprising variou...
The effect of a newly developed osmium(VI) nitrido complex, 1, on breast cancer stem cells (CSCs) is...
Cancer stem cells (CSCs) are thought of as a clinically pertinent subpopulation of tumors, partly re...
Immunogenic cell death (ICD) offers a method of stimulating the immune system to attack and remove c...
Copper(II) complexes bearing nonsteroidal anti-inflammatory drugs (NSAIDs) are known to potently kil...
Breast cancer stem cells (CSCs) are a sub-population of tumour cells that can promote breast cancer ...
The effect of a newly developed osmium(VI) nitrido complex, 1, on breast cancer stem cells (CSCs) is...
Intracellular redox modulation offers a viable approach to effectively remove cancer stem cells (CSC...
Cancer stem cells (CSCs) are thought to be responsible for cancer relapse. CSCs are a subtype of can...
The effect of a newly developed osmium(VI) nitrido complex, <b>1</b>, on breast cancer stem cells (C...
Cancer stem cells (CSCs) are thought to be responsible for cancer relapse. CSCs are a subtype of can...
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphi...
We report the anti-breast cancer stem cell (CSC) properties of a series of Group 10-bis(azadiphosphi...
The cancer stem cell (CSC) potency of a series of structurally analogous Group 10-azadiphosphine met...