The latent viral reservoir formed by HIV-1, mainly in CD4 + T cells, is responsible for the failure of antiretroviral therapy (ART) to achieve a complete elimination of the virus in infected individuals. We previously determined that CD4 + T cells from individuals with chronic myeloid leukemia (CML) on treatment with dasatinib are resistant to HIV-1 infection ex vivo. The main mechanism for this antiviral effect is the preservation of SAMHD1 activity. In this study, we aimed to evaluate the impact of dasatinib on the viral reservoir of HIV-infected individuals with CML who were on simultaneous treatment with ART and dasatinib. Due to the low estimated incidence of HIV-1 infection and CML (1:65,000), three male individuals were recruited in ...
Objectives: The latent reservoir for HIV-1 in resting memory CD4+ T cells is a major barrier to erad...
HIV-1 infection cannot be cured due to reservoirs formed early after infection. Decreasing the massi...
The latent reservoir of HIV is the major barrier to cure. Stimulation of latently-infected T cells r...
The latent viral reservoir formed by HIV-1, mainly in CD4 + T cells, is responsible for the failure ...
Massive activation of infected CD4+ T cells during acute HIV-1 infection leads to reservoir seeding ...
HIV-1 infection remains incurable despite the efficient combined antiretroviral therapy (cART) due t...
Current antiretroviral treatment (ART) may control HIV-1 replication but it cannot cure the infectio...
Monográfico con los resúmenes del Ninth International Workshop on HIV Persistence during Therapy 10-...
A latent viral reservoir that resides in resting CD4 + T cells represents a major barrier for eradic...
Combination antiretroviral therapy for HIV-1 suppresses viral replication, but is not curative. HIV-...
International audienceThe role of immune checkpoints (ICPs) in both anti-HIV T cell exhaustion and H...
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels in infected individuals ...
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral th...
peer reviewedOBJECTIVE: HIV-1 reservoirs are the major hurdle to virus clearance in combination anti...
Despite its great success, antiretroviral therapy (ART) fails to improve HIV-1-specific T-cell respo...
Objectives: The latent reservoir for HIV-1 in resting memory CD4+ T cells is a major barrier to erad...
HIV-1 infection cannot be cured due to reservoirs formed early after infection. Decreasing the massi...
The latent reservoir of HIV is the major barrier to cure. Stimulation of latently-infected T cells r...
The latent viral reservoir formed by HIV-1, mainly in CD4 + T cells, is responsible for the failure ...
Massive activation of infected CD4+ T cells during acute HIV-1 infection leads to reservoir seeding ...
HIV-1 infection remains incurable despite the efficient combined antiretroviral therapy (cART) due t...
Current antiretroviral treatment (ART) may control HIV-1 replication but it cannot cure the infectio...
Monográfico con los resúmenes del Ninth International Workshop on HIV Persistence during Therapy 10-...
A latent viral reservoir that resides in resting CD4 + T cells represents a major barrier for eradic...
Combination antiretroviral therapy for HIV-1 suppresses viral replication, but is not curative. HIV-...
International audienceThe role of immune checkpoints (ICPs) in both anti-HIV T cell exhaustion and H...
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels in infected individuals ...
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral th...
peer reviewedOBJECTIVE: HIV-1 reservoirs are the major hurdle to virus clearance in combination anti...
Despite its great success, antiretroviral therapy (ART) fails to improve HIV-1-specific T-cell respo...
Objectives: The latent reservoir for HIV-1 in resting memory CD4+ T cells is a major barrier to erad...
HIV-1 infection cannot be cured due to reservoirs formed early after infection. Decreasing the massi...
The latent reservoir of HIV is the major barrier to cure. Stimulation of latently-infected T cells r...