In the mammalian embryo, epiblast cells must exit the naive state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency progression in defined conditions in vitro. However, our understanding of the molecular cascades and gene networks involved in the exit from naive pluripotency remains fragmentary. Here, we employed a combination of genetic screens in haploid ESCs, CRISPR/Cas9 gene disruption, large-scale transcriptomics and computational systems biology to delineate the regulatory circuits governing naive state exit. Transcriptome profiles for 73 ESC lines deficient for regulators of the exit from naive pluripotency predominantly manifest delays on ...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions abo...
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions abo...
In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative pluripotency...
Contains fulltext : 168894.pdf (preprint version ) (Open Access)Mouse embryonic st...
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Relea...
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Relea...
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Relea...
SummaryNaive pluripotency is manifest in the preimplantation mammalian embryo. Here we determine tra...
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In respo...
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In respo...
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In respo...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions abo...
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions abo...
In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative pluripotency...
Contains fulltext : 168894.pdf (preprint version ) (Open Access)Mouse embryonic st...
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Relea...
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Relea...
Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Relea...
SummaryNaive pluripotency is manifest in the preimplantation mammalian embryo. Here we determine tra...
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In respo...
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In respo...
The foundations of mammalian development lie in a cluster of embryonic epiblast stem cells. In respo...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Pluripotent stem cells of different embryonic origin respond to distinct signaling pathways. Embryon...
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions abo...
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions abo...