Purpose We present here a Zr-89-labeled inhibitor of prostate-specific membrane antigen (PSMA) as a complement to the already established F-18- or Ga-68-ligands. Procedures The precursor PSMA-DFO (ABX) was used for Zr-89-labeling. This is not an antibody, but a peptide analogue of the precursor for the production of [Lu-177]Lu-PSMA-617. The ligand [Zr-89]Zr-PSMA-DFO was compared with [Ga-68]Ga-PSMA-11 and [F-18]F-JK-PSMA-7 in vitro by determination of the K-d value, cellular uptake, internalization in LNCaP cells, biodistribution studies with LNCaP prostate tumor xenografts in mice, and in vivo by small-animal PET imaging in LNCaP tumor mouse models. A first-in-human PET was performed with [Zr-89]Zr-PSMA-DFO on a patient presenting with a b...
Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid cleara...
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and small-molecule...
Contains fulltext : 167159.pdf (publisher's version ) (Open Access)Prostate-specif...
The short half-life of existing prostate-specific membrane antigen (PSMA) tracers limits their time ...
The short half-life of existing prostate-specificmembraneantigen (PSMA) tracers limits their time fo...
Prostate-specific membrane antigen (PSMA), expressed by most prostate carcinomas (PCa), is a promisi...
In preclinical trials, the recently developed tracer 2-methoxy-18F-DCFPyL (18F-JK-prostate-specific ...
PURPOSE: Prostate-specific membrane antigen (PSMA)-targeted PET/CT has become increasingly important...
The prostate-specific membrane antigen (PSMA)-targeted radiotracers Ga-68/Lu-177-PSMA-I&T and Tc...
Prostate specific membrane antigen (PSMA) expressed by the vast majority of prostate cancers (PCa) i...
Radiohalogenated agents are often the first line of pursuit in the development of new radiopharmaceu...
Contains fulltext : 205486.pdf (publisher's version ) (Closed access)The aim was t...
In the past two decades, extensive efforts have been made to develop agents targeting prostate-speci...
As precision medicine evolves, the contribution of molecular imaging to the management of prostate c...
Because traditional endpoints in oncology trials are not always applicable for metastatic prostate c...
Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid cleara...
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and small-molecule...
Contains fulltext : 167159.pdf (publisher's version ) (Open Access)Prostate-specif...
The short half-life of existing prostate-specific membrane antigen (PSMA) tracers limits their time ...
The short half-life of existing prostate-specificmembraneantigen (PSMA) tracers limits their time fo...
Prostate-specific membrane antigen (PSMA), expressed by most prostate carcinomas (PCa), is a promisi...
In preclinical trials, the recently developed tracer 2-methoxy-18F-DCFPyL (18F-JK-prostate-specific ...
PURPOSE: Prostate-specific membrane antigen (PSMA)-targeted PET/CT has become increasingly important...
The prostate-specific membrane antigen (PSMA)-targeted radiotracers Ga-68/Lu-177-PSMA-I&T and Tc...
Prostate specific membrane antigen (PSMA) expressed by the vast majority of prostate cancers (PCa) i...
Radiohalogenated agents are often the first line of pursuit in the development of new radiopharmaceu...
Contains fulltext : 205486.pdf (publisher's version ) (Closed access)The aim was t...
In the past two decades, extensive efforts have been made to develop agents targeting prostate-speci...
As precision medicine evolves, the contribution of molecular imaging to the management of prostate c...
Because traditional endpoints in oncology trials are not always applicable for metastatic prostate c...
Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid cleara...
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and small-molecule...
Contains fulltext : 167159.pdf (publisher's version ) (Open Access)Prostate-specif...