Longitudinal reproducibility of attenuation measurements on virtual unenhanced images: multivendor dual-energy CT evaluation

Objectives The accuracy of virtual unenhanced (VUE) images has been extensively investigated, yet data on their longitudinal reproducibility is limited. The study purpose was to evaluate the longitudinal reproducibility of VUE attenuation measurements on three different dual-energy CT (DECT) scanner types. Methods A total of 137 patients with repeated abdominal DECT either on a rapid kV switching (rsDECT; n = 46), a dual-layer detector (dlDECT; n = 43), or a dual-source scanner (dsDECT; n = 48) were retrospectively included. Attenuation was measured on VUE and corresponding contrast-enhanced images in the liver, spleen, kidneys, aorta, portal vein, and fat. Longitudinal reproducibility was evaluated by calculating the absolute inter-scan differences (HU) and the inter-scan variation (%). Measurement pairs with differences <= 10 HU were considered reproducible. Influence of contrast-enhanced attenuation on VUE reproducibility was analyzed using linear regression. Results The scanner-specific cohorts showed similar age (p-range: 0.35-0.99), sex (p-range: 0.68-1), body weight (p-range: 0.26-0.87), body diameter (p-range: 0.34-0.76), and inter-scan time (p-range: 0.52-0.83). In total, 94.9% of VUE measurements were reproducible for rsDECT, 93.8% for dlDECT, and 90.6% for dsDECT. Overall inter-scan variation was lowest in fat (4.0 (1.7-8.2)%) and highest in tissues with high contrast enhancement: the aorta (13.3 (4.6-21.3)%), portal vein (10.8 (5.7-19.8)%), and kidneys (10.7 (3.9-18.0)%). Significant differences in inter-scan variation were found between the scanner types for the aorta, portal vein, kidneys, and spleen. Inter-scan differences in contrast-enhanced attenuation significantly influenced inter-scan differences in VUE attenuation (p < 0.001; t-ratio: 4.34). Conclusions Longitudinal reproducibility of VUE attenuation was high for all scanners, yet inter-scan variation of VUE attenuation was influenced by contrast enhancement, showing greatest magnitude and discrepancy between scanner types in vessels and the kidneys