Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, making "CR mimetics" of great interest. CR targets nutrient-sensing pathways centering on mTORC1. The mTORC1 inhibitor, rapamycin, is considered a potential CR mimetic and is proven to counteract age-related muscle loss. Therefore, we tested whether rapamycin acts via similar mechanisms as CR to slow muscle aging. Here we show that long-term CR and rapamycin unexpectedly display distinct gene expression profiles in geriatric mouse skeletal muscle, despite both benefiting aging muscles. Furthermore, CR improves muscle integrity in mice with nutrient-insens...
The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pat...
SummaryThe evolutionarily conserved target of rapamycin (TOR) signaling controls growth, metabolism,...
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and function. Give...
Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restr...
Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately...
There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associa...
Skeletal muscle comprises about 40% of body mass and plays an essential role in metabolism and movem...
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic...
SummaryWe analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse...
The balance between protein synthesis and degradation (proteostasis) is a determining factor for mus...
Age-induced mitochondrial DNA deletion mutations may underlie cell loss and tissue aging. Rapamycin ...
The mechanistic target of rapamycin (mTOR) signaling pathway plays a central role in aging and a num...
Rapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds...
SummaryCalorie restriction (CR) extends life span and ameliorates age-related pathologies in most sp...
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads...
The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pat...
SummaryThe evolutionarily conserved target of rapamycin (TOR) signaling controls growth, metabolism,...
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and function. Give...
Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restr...
Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately...
There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associa...
Skeletal muscle comprises about 40% of body mass and plays an essential role in metabolism and movem...
Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic...
SummaryWe analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse...
The balance between protein synthesis and degradation (proteostasis) is a determining factor for mus...
Age-induced mitochondrial DNA deletion mutations may underlie cell loss and tissue aging. Rapamycin ...
The mechanistic target of rapamycin (mTOR) signaling pathway plays a central role in aging and a num...
Rapamycin (RM), a drug that inhibits the mechanistic target of rapamycin (mTOR) pathway and responds...
SummaryCalorie restriction (CR) extends life span and ameliorates age-related pathologies in most sp...
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads...
The mammalian target of rapamycin complex 1 (mTORC1) is a central node in a network of signaling pat...
SummaryThe evolutionarily conserved target of rapamycin (TOR) signaling controls growth, metabolism,...
Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and function. Give...