Overlapping genetic architecture between Parkinson disease and melanoma
- Dube, Umber
- Ibanez, Laura
- Budde, John P.
- Benitez, Bruno A.
- Davis, Albert A.
- Harari, Oscar
- Iles, M. M.
- Law, Matthew H.
- Brown, Kevin M.
- Agee, Michelle
- Alipanahi, Babak
- Auton, Adam
- Bell, Robert K.
- Bryc, Katarzyna
- Elson, Sarah L.
- Fontanillas, Pierre
- Furlotte, Nicholas A.
- Hinds, David A.
- Huber, Karen E.
- Kleinman, Aaron
- Litterman, Nadia K.
- McCreight, Jennifer C.
- McIntyre, Matthew H.
- Mountain, Joanna L.
- Noblin, Elizabeth S.
- Northover, Carrie A.M.
- Pitts, Steven J.
- Sathirapongsasuti, J. Fah
- Sazonova, Olga V.
- Shelton, Janie F.
- Shringarpure, Suyash
- Tian, Chao
- Tung, Joyce Y.
- Vacic, Vladimir
- Wilson, Catherine H.
- Bishop, D. T.
- Lee, J. E.
- Brossard, M.
- Martin, N. G.
- Moses, E. K.
- Song, F.
- Barrett, J. H.
- Kumar, R.
- Easton, D. F.
- Pharoah, P. D.
- Swerdlow, A. J.
- Kypreou, K. P.
- Taylor, J. C.
- Harland, M.
- Randerson-Moor, J.
- Akslen, L. A.
- Andresen, P. A.
- Avril, M. F.
- Azizi, E.
- Scarrà, G. B.
- Debniak, T.
- Duffy, D. L.
- Elder, D. E.
- Fang, S.
- Friedman, E.
- Galan, P.
- Ghiorzo, P.
- Gillanders, E. M.
- Goldstein, A. M.
- Gruis, N. A.
- Hansson, J.
- Helsing, P.
- Hočevar, M.
- Höiom, V.
- Ingvar, C.
- Kanetsky, P. A.
- Chen, W. V.
- Landi, M. T.
- Lang, J.
- Lathrop, G. M.
- Lubiński, J.
- Mackie, R. M.
- Mann, G. J.
- Molven, A.
- Montgomery, G. W.
- Novaković, S.
- Olsson, H.
- Puig, S.
- Puig-Butille, J. A.
- Wu, W.
- Qureshi, A. A.
- Radford-Smith, G. L.
- van der Stoep, N.
- van Doorn, R.
- Whiteman, D. C.
- Craig, J. E.
- Schadendorf, E.
- Simms, L. A.
- Burdon, K. P.
- Nyholt, D. R.
- Pooley, K. A.
- Orr, N.
- Stratigos, A. J.
- Cust, A. E.
- Ward, S. V.
- Hayward, N. K.
- Han, J.
- Schulze, H. J.
- Dunning, A. M.
- Bishop, J. A.
- Demenais, F.
- Amos, C. I.
- MacGregor, S.
- Cruchaga, Carlos
- other, and
DOIAbstract
Epidemiologic studies have reported inconsistent results regarding an association between Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic architecture between these diseases can support epidemiologic findings and identify common risk genes and biological pathways. Here, we apply polygenic, linkage disequilibrium-informed methods to the largest available case–control, genome-wide association study summary statistic data for melanoma and PD. We identify positive and significant genetic correlation (correlation: 0.17, 95% CI 0.10–0.24; P = 4.09 × 10−06) between melanoma and PD. We further demonstrate melanoma and PD-inferred gene expression to overlap across tissues (correlation: 0.14, 95% CI 0.06 to 0.22; ...
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