Add to ORKGA new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds 6a, 6b and 6d exhibited strong anti-bacterial effects against the Gram-positive bacteria. The oxidation of synthesized compounds to sulfinyl and sulfonyl bearing analogues did not improve the activity. © 2020 National Research Center of Medical Sciences. All rights reserved
Nitrogen heterocycles are of a special interest because they constitute an important class of natura...
The aim of research. Synthesize new 2,5-substituted-4-thiazolinone derivatives and evaluate their an...
1212-1219The synthesis of a series of N-(4-substitutedbenzyl)-2-amino-4-aryl-1,3-thiazoles/N-(4-subs...
In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-...
Abstract: In the present study we report the synthesis and antibacterial activity of a new series 2-...
Department of P. G. Studies and Researoh in Chemistry, Mangalore University, Mangalagangothri-574 19...
A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionami...
A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazol...
Introduction: Nitrofurans and nitroimidazoles are broad-spectrum antimicrobial agents, which affect ...
Department of Chemistry, University of Jammu, Jammu-180 001 Manuscript received 18 July 1990, revis...
A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids whic...
A number of new 2,5-disubstituted 1,3,4-thiadiazole and their S- or N-substituted derivatives as wel...
Introduction: The increasing drug resistance of bacteria against different antibiotics is a cause of...
In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (...
Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5...
Nitrogen heterocycles are of a special interest because they constitute an important class of natura...
The aim of research. Synthesize new 2,5-substituted-4-thiazolinone derivatives and evaluate their an...
1212-1219The synthesis of a series of N-(4-substitutedbenzyl)-2-amino-4-aryl-1,3-thiazoles/N-(4-subs...
In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-...
Abstract: In the present study we report the synthesis and antibacterial activity of a new series 2-...
Department of P. G. Studies and Researoh in Chemistry, Mangalore University, Mangalagangothri-574 19...
A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionami...
A new series of thiadiazole-enaminones 4 were synthesized via reactions of 5-acetyl-1,3,4-thiadiazol...
Introduction: Nitrofurans and nitroimidazoles are broad-spectrum antimicrobial agents, which affect ...
Department of Chemistry, University of Jammu, Jammu-180 001 Manuscript received 18 July 1990, revis...
A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids whic...
A number of new 2,5-disubstituted 1,3,4-thiadiazole and their S- or N-substituted derivatives as wel...
Introduction: The increasing drug resistance of bacteria against different antibiotics is a cause of...
In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (...
Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5...
Nitrogen heterocycles are of a special interest because they constitute an important class of natura...
The aim of research. Synthesize new 2,5-substituted-4-thiazolinone derivatives and evaluate their an...
1212-1219The synthesis of a series of N-(4-substitutedbenzyl)-2-amino-4-aryl-1,3-thiazoles/N-(4-subs...