The carnitine pathway is dysregulated in asthma in an oral corticosteroid-independent mechanism

Reinke, S
Naz, S
Kermani, N
Chaleckis, R
Kolmert, J
Strom, M
Wheelock, A
Djukanovic, R
Chung, F
Adcock, I
Dahlen, S-E
Wheelock, C

Open link

Publication date

November 2021

DOI

10.1183/13993003.congress-2021.OA1290

Publisher

European Respiratory Society (ERS)

Journal

European Respiratory Journal

Abstract

Background: Asthma is a heterogeneous disease with poorly defined phenotypes. Aim: To identify metabolic dysregulations associated with asthma severity and evaluate the effects of asthma medication upon observed metabotypes. Methods: Baseline urine was collected from healthy controls (HC, n=108), mild-to-moderate asthmatics (MMA, n=87) and severe asthmatics (SA, n=418) from the U-BIOPRED cohort. 12-18 month longitudinal samples were collected from the SA cohort (n=305). Metabolomic data were acquired using mass spectrometry and analyzed using multivariate statistics. Gene set variation analysis (GSVA) was performed on bronchial brushing transcriptomic data. Results: 90 metabolites were identified with 40 altered in asthma (FDR<0.1). Multiva...