Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because of the lack of an established biomarker. Neuromelanin-magnetic resonance imaging (NM-MRI) is an emerging biomarker of nigral depigmentation indexing the loss of melanized neurons but has unknown prospective diagnostic and tracking performance in multicenter settings. Objectives: The aim was to investigate the diagnostic accuracy of NM-MRI in early PD in a multiprotocol setting and to determine and compare serial NM-MRI changes in PD and controls. Methods: In this longitudinal case–control 3 T MRI study, 148 patients and 97 controls were included from six UK clinical centers, of whom 140 underwent a second scan after 1.5 to 3 years. An automa...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nig...
Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because...
Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because...
Introduction: Neuromelanin-sensitive (NM) magnetic resonance imaging visualizes dopaminergic neurona...
International audienceBackgroundDevelopment of reliable and accurate imaging biomarkers of dopaminer...
International audienceBackgroundDevelopment of reliable and accurate imaging biomarkers of dopaminer...
© 2017 – IOS Press and the authors. All rights reservedBackground: A specific T1-weighted magnetic r...
The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many substantia ...
Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nig...
Purpose:To investigate the pattern of neuromelanin signal intensity loss within the substantia nigra...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nig...
Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because...
Background: Clinical diagnosis and monitoring of Parkinson's disease (PD) remain challenging because...
Introduction: Neuromelanin-sensitive (NM) magnetic resonance imaging visualizes dopaminergic neurona...
International audienceBackgroundDevelopment of reliable and accurate imaging biomarkers of dopaminer...
International audienceBackgroundDevelopment of reliable and accurate imaging biomarkers of dopaminer...
© 2017 – IOS Press and the authors. All rights reservedBackground: A specific T1-weighted magnetic r...
The diagnosis of Parkinson's disease (PD) occurs after pathogenesis is advanced and many substantia ...
Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nig...
Purpose:To investigate the pattern of neuromelanin signal intensity loss within the substantia nigra...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which the major pathologic s...
Purpose: To investigate the pattern of neuromelanin signal intensity loss within the substantia nig...