Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

International severe asthma registry (ISAR) : protocol for a global registry

FitzGerald, J. Mark
Tran, Trung N.
Alacqua, Marianna
Altraja, Alan
Backer, Vibeke
Bjermer, Leif
Bjornsdottir, Unnur
Bourdin, Arnaud
Brusselle, Guy
Bulathsinhala, Lakmini
Busby, John
Canonica, Giorgio W.
Carter, Victoria
Chaudhry, Isha
Cho, You Sook
Christoff, George
Cosio, Borja G.
Costello, Richard W.
Eleangovan, Neva
Gibson, Peter G.
Heaney, Liam G.
Heffler, Enrico
Hew, Mark
Hosseini, Naeimeh
Iwanaga, Takashi
Jackson, David J.
Jones, Rupert
Koh, Mariko S.
Le, Thao
Lehtimäki, Lauri
Ludviksdottir, Dora
Maitland-van der Zee, Anke Hilse
Menzies-Gow, Andrew
Murray, Ruth B.
Papadopoulos, Nikolaos G.
Perez-de-Llano, Luis
Peters, Matthew
Pfeffer, Paul E.
Popov, Todor A.
Porsbjerg, Celeste M.
Price, Chris A.
Rhee, Chin K.
Sadatsafavi, Mohsen
Tohda, Yuji
Eileen, Wang
Wechsler, Michael E.
Zangrilli, James
Price, David

August 2020

Acknowledgements The authors thank the following individuals who contributed to the initial set-up o...

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Mikus M. S.
Kolmert J.
Andersson L. I.
Ostling J.
Knowles R. G.
Gomez C.
Ericsson M.
Thorngren J. -O.
Khoonsari P. E.
Dahlen B.
Kupczyk M.
de Meulder B.
Auffray C.
Bakke P. S.
Beghe Bianca
Bel E. H.
Caruso M.
Chanez P.
Chawes B.
Fowler S. J.
Gaga M.
Geiser T.
Gjomarkaj M.
Horvath I.
Howarth P. H.
Johnston S. L.
Joos G.
Krug N.
Montuschi P.
Musial J.
Nizankowska-Mogilnicka E.
Olsson H. K.
Papi A.
Rabe K. F.
Sandstrom T.
Shaw D. E.
Siafakas N. M.
Uhlen M.
Riley J. H.
Bates S.
Middelveld R. J. M.
Wheelock C. E.
Chung K. F.
Adcock I. M.
Sterk P. J.
Djukanovic R.
Nilsson P.
Dahlen S. -E.
James A.
Ahmed H.
Balgoma D.
Bansal A. T.
Baribaud F.
Bigler J.
Billing B.
Bisgaard H.
Boedigheimer M. J.
Bonnelykke K.
Brandsma J.
Brinkman P.
Bucchioni E.
Burg D.
Bush A.
Chaiboonchoe A.
Checa T.
Compton C. H.
Corfield J.
Cunoosamy D.
D'Amico A.
Emma R.
Erpenbeck V. J.
Erzen D.
Fichtner K.
Fitch N.
Fleming L. J.
Formaggio E.
Frey U.
Gahlemann M.
Goss V.
Guo Y. -K.
Hashimoto S.
Haughney J.
Hedlin G.
Hekking P. -P. W.
Higenbottam T.
Hohlfeld J. M.
Holweg C. T. J.
Knox A. J.
Konradsen J.
Lazarinis N.
Lefaudeux D.
Li T.
Loza M. J.
Lutter R.
Manta A.
Masefield S.
Matthews J. G.
Mazein A.
Meiser A.
Miralpeix M.
Mores N.
Murray C. S.
Myles D.
Naz S.
Nordlund B.
Pahus L.
Pandis I.
Pavlidis S.
Postle A.
Powel P.
Rao N.
Reinke S.
Roberts A.
Roberts G.
Rowe A.
Schofield J. P. R.
Seibold W.
Selby A.
Sigmund R.
Singer F.
Sjodin M.
Skipp P. J.
Sousa A. R.
Sun K.
Thornton B.
Uddin M.
van Aalderen W. M.
van Geest M.
Vestbo J.
Vissing N. H.
Wagener A. H.
Wagers S. S.
Weiszhart Z.
Wheelock C. E.
Wheelock A.
Wilson S. J.
Yasinska V.
Brusselle G. G.
Campbell D. A.
Contoli M.
Damm K.
de Rudder I.
Delin I.
Devautour C.
Duplaga M.
Eduards M.
Ek A.
Ekstrom T.
Figiel E.
Gaber F.
Gauw S.
Gawlewicz-Mroczka A.
Gerding D.
Haque S.
Hewitt L.
Hiemstra P. S.
Holgate S. T.
Holloway J.
Kania A.
Kanniess F.
Karlsson O.
Kips J. C.
Kumlin M.
Lantz A. -S.
Lazarinis N.
Magnussen H.
Mallia P.
Martling I.
Meziane L.
Oikonomidou E.
Olsson M.
Pace E.
Papadopouli E.
Papadopoulos N.
Plataki M.
Profita M.
Reinius L. E.
Richter K.
Robinson D. S.
Romagnoli M.
Samara K.
Schelfhout V.
Skedinger M.
Stamataki E.
ten Brinke A.
Vachier I.
Wallen-Nielsen E.
van Veen I.
Weersink E.
Wilson S. J.
Yasinska V.
Zervas E.
Ziolkowska-Graca B.

January 2022

Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma bioma...

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma

Rossios, Christos
Pavlidis, Stelios
Hoda, Uruj
Kuo, Chih Hsi
Wiegman, Coen
Russell, Kirsty
Sun, Kai
Loza, Matthew J.
Baribaud, Frederic
Durham, Andrew L.
Ojo, Oluwaseun
Lutter, Rene
Rowe, Anthony
Bansal, Aruna
Auffray, Charles
Sousa, Ana
Corfield, Julie
Djukanovic, Ratko
Guo, Yike
Sterk, Peter J.
Chung, Kian Fan
Adcock, Ian M.
Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) Consortia Project Team

February 2018

Background: Sputum analysis in asthmatic patients is used to define airway inflammatory processes an...

Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

Denton, Eve
Price, David B
Tran, Trung N
Canonica, G Walter
Menzies-Gow, Andrew
FitzGerald, J Mark
Sadatsafavi, Mohsen
Perez de Llano, Luis
Christoff, George
Quinton, Anna
Rhee, Chin Kook
Brusselle, Guy
Ulrik, Charlotte
Lugogo, Njira
Hore-Lacy, Fiona
Chaudhry, Isha
Bulathsinhala, Lakmini
Murray, Ruth B
Carter, Victoria A
Hew, Mark

July 2021

Funding: ISAR is conducted by Optimum Patient Care Global Ltd, and co-funded by OPC Global Ltd and A...

Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry

Eve Denton
David B. Price
Trung N. Tran
G. Walter Canonica
Andrew N. Menzies-Gow
J. Mark FitzGerald
Mohsen Sadatsafavi
Luis Perez de Llano
George C. Christoff
Anna Quinton
Chin Kook Rhee
G.G.O. (Guy) Brusselle
Charlotte Suppli Ulrik
Njira Lugogo
Fiona Hore-Lacy
Isha Chaudhry
Lakmini Bulathsinhala
Ruth Murray
Victoria A. Carter
Mark Hew

July 2021

Background: Allergy, eosinophilic inflammation, and epithelial dysregulation are implicated in sever...

Cluster analysis of inflammatory biomarker expression in the international severe asthma registry

Denton, Eve
Price, David B.
Tran, Trung N.
Canonica, G. Walter
Menzies-Gow, Andrew
FitzGerald, J. Mark
Sadatsafavi, Mohsen
Perez de Llano, Luis
Christoff, George
Quinton, Anna
Kook Rhee, Chin
Brusselle, Guy
Ulrik, Charlotte
Lugogo, Njira
Hore-Lacy, Fiona
Chaudhry, Isha
Bulathsinhala, Lakmini
Murray, Ruth B.
Carter, Victoria A.
Hew, Mark

January 2021

Background: Allergy, eosinophilic inflammation, and epithelial dysregulation are implicated in sever...

Eosinophilic and non-eosinophilic asthma : an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort

Heaney, Liam G
Perez de Llano, Luis
Al-Ahmad, Mona
Backer, Vibeke
Busby, John
Canonica, Giorgio Walter
Christoff, George
Cosio, Borja G.
FitzGerald, J. Mark
Heffler, Enrico
Iwanaga, Takashi
Jackson, David J
Menzies-Gow, Andrew
Papadopoulos, Nikolaos G
Papaioannou, Andriana I.
Pfeffer, Paul E
Popov, Todor A
Porsbjerg, Celeste M.
Rhee, Chin Kook
Sadatsafavi, Mohsen
Tohda, Yuji
Eileen, Wang
Wechsler, Michael E
Alacqua, Marianna
Altraja, Alan
Bjermer, Leif
Björnsdóttir, Unnur S.
Bourdin, Arnaud
Brusselle, Guy
Buhl, Roland
Costello, Richard W
Hew, Mark
Siyue, Mariko Koh
Lehmann, Sverre
Lehtimäki, Lauri
Peters, Matthew
Taillé, Camille
Taube, Christian
Tran, Trung N
Tran, Trung N
Bulathsinhala, Lakmini
Carter, Victoria A
Chaudhry, Isha
Eleangovan, Nevaashni
Hosseini, Naeimeh
Kerkhof, Marjan
Murray, Ruth B
Price, Chris
Price, David

September 2021

FUNDING/SUPPORT: This study was conducted by the Observational and Pragmatic Research Institute (OPR...

Real-life biomarker response to anti-IL5 and anti-IgE therapies in severe asthma patients

Burkill, Sarah
Porsbjerg, Celeste M.
Bourdin, Arnaud
Tran, Trung N
Martin, Neil
Katial, Rohit
Barker, Peter
Wechsler, Michael E
Maspero, Jorge F
Bosnic-Anticevich, Sinthia
Chung, Li Ping
Katsoulotos, Gregory
Christoff, George
Popov, Todor A
Sadatsafavi, Mohsen
Torres-Duque, Carlos A.
Ulrik, Charlotte
Assing, Karin Dahl
Hansen, Susanne
Altraja, Alan
Lehtimäki, Lauri A.
Papadopoulos, Nikolaos G
Kostikas, Konstantinos
Salvi, Sundeep
Costello, Richard W
Puggioni, Francesca
Iwanaga, Takashi
Rhee, Chin Kook
Al-Ahmad, Mona
Larenas-Linnemann, Désirée
Fonseca, João A.
Amaral, Rita
Al-Lehebi, Riyad
Perez de Llano, Luis
Kirenga, Bruce
Tsai, Ming-Ju
Mahboub, Bassam
Pfeffer, Paul E
Henley, William
Liu, Yang
Lyu, Juntao
Goh, Celine
Uthaman, Thendral
Price, David
ISAR IGNITE

November 2023

Funding: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte L...

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

Wilson, Susan J.
Ward, Jonathan A.
Sousa, Ana
Corfield, Julie
Bansal, Aruna T.
De Meulder, Bertrand
Lefaudeux, Diane
Auffray, Charles
Loza, Matthew J.
Baribaud, Frederic
Fitch, Neil
Sterk, Peter J.
Chung, Kian
Gibeon, David
Sun, Kai
Guo, Yi-Ke
Adcock, Ian
Djukanovic, Ratko
Dahlen, Barbro
Chanez, Pascal
Shaw, Dominick
Krug, Norbert
Hohlfeld, Jens
Sandtrom, Thomas
Howarth, Peter H.
on behalf of the U-BIOPRED Study Group

November 2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma...

A clustering analysis of eosinophilic asthmatics

Nekoee Zahraei, Halehsadat
SCHLEICH, FLorence
HENKET, Monique
PAULUS, Virginie
Gerday, Sara
GUISSARD, Françoise
Donneau, Anne-Françoise
LOUIS, Renaud

May 2022

editorial reviewedIntroduction Eosinophilic asthma is well recognized asthma phenotype associated w...

Development of the International Severe Asthma Registry (ISAR) : A Modified Delphi Study

Bulathsinhala, Lakmini
Eleangovan, Nevaashni
Heaney, Liam G.
Menzies-Gow, Andrew
Gibson, Peter G.
Peters, Matthew
Hew, Mark
van Boven, Job F.M.
Lehtimäki, Lauri
van Ganse, Eric
Belhassen, Manon
Harvey, Erin S.
Perez de Llano, Luis
Maitland-van der Zee, Anke H.
Papadopoulos, Nikolaos G.
FitzGerald, J. Mark
Porsbjerg, Celeste
Canonica, G. Walter
Backer, Vibeke
Rhee, Chin Kook
Verhamme, Katia M.C.
Buhl, Roland
Cosio, Borja G.
Carter, Victoria
Price, Chris
Le, Thao
Stagno d'Alcontres, Martina
Gopalan, Gokul
Tran, Trung N.
Price, David

September 2019

This study is cofunded by Optimum Patient Care Global and AstraZeneca.Peer reviewedPostprin

Towards clinically applicable biomarkers for asthma - An EAACI position paper

Diamant, Zuzana
Vijverberg, Susanne
Alving, Kjell
Bakirtas, Arzu
Bjermer, Leif
Custovic, Adnan
Dahlen, Sven-Erik
Gaga, Mina
Gerth van Wijk, Roy
Del Giacco, Stefano
Hamelmann, Eckard
Heaney, Liam
Heffler, Enrico
Kalayci, Ömer
Kostikas, Konstantinos
Lutter, Rene
Olin, Anna-Carin
Sergejeva, Svetlana
Simpson, Angela
Sterk, Peter J
Tufvesson, Ellen
Agache, Ioana
Seys, Sven F

January 2019

Inflammation, structural and functional abnormalities within the airways are key features of asthma....

Severe asthma exists despite suppressed tissue inflammation: Findings of the U-BIOPRED study

Wilson, Susan J.
Ward, Jonathan A.
Sousa, Ana R.
Corfield, Julie
Bansal, Aruna T.
Meulder, Bertrand de
Lefaudeux, Diane
Auffray, Charles
Loza, Matthew J.
Baribaud, Frédéric
Fitch, Neil
Sterk, Peter J.
Chung, Kian Fan
Gibeon, David
Sun, Kai
Guo, Yi-Ke
Adcock, Ian M.
Djukanovic, Ratko
Dahlén, Barbro
Chanez, Pascal
Shaw, Dominick E.
Krug, Norbert
Hohlfeld, Jens
Sandström, Thomas
Howarth, Peter H.

January 2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma...

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Lefaudeux, D
De Meulder, B
Loza, Mj
Peffer, N
Rowe, A
Baribaud, F
Bansal, At
Lutter, R
Sousa, Ar
Corfield, J
Pandis, I
Bakke, Ps
Caruso, M
Chanez, P
Dahl\ue9n, Se
Fleming, Lj
Fowler, Sj
Horvath, I
Krug, N
Montuschi, Paolo (ORCID:0000-0001-5589-1750)
Sanak, M
Sandstrom, T
Shaw, De
Singer, F
Sterk, Pj
Roberts, G
Adcock, Im
Djukanovic, R
Auffray, C
Chung, Kf
BIOPRED Study Group, U.

January 2017

BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma tr...

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.

Wilson, SJ
Ward, JA
Sousa, AR
Corfield, J
Bansal, AT
De Meulder, B
Lefaudeux, D
Auffray, C
Loza, MJ
Baribaud, F
Fitch, N
Sterk, PJ
Chung, KF
Gibeon, D
Sun, K
Guo, YK
Adcock, I
Djukanovic, R
Dahlen, B
Chanez, P
Shaw, D
Krug, N
Hohlfeld, J
Sandström, T
Howarth, PH
U-BIOPRED Study Group

August 2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma...

International severe asthma registry (ISAR) : protocol for a global registry

FitzGerald, J. Mark
Tran, Trung N.
Alacqua, Marianna
Altraja, Alan
Backer, Vibeke
Bjermer, Leif
Bjornsdottir, Unnur
Bourdin, Arnaud
Brusselle, Guy
Bulathsinhala, Lakmini
Busby, John
Canonica, Giorgio W.
Carter, Victoria
Chaudhry, Isha
Cho, You Sook
Christoff, George
Cosio, Borja G.
Costello, Richard W.
Eleangovan, Neva
Gibson, Peter G.
Heaney, Liam G.
Heffler, Enrico
Hew, Mark
Hosseini, Naeimeh
Iwanaga, Takashi
Jackson, David J.
Jones, Rupert
Koh, Mariko S.
Le, Thao
Lehtimäki, Lauri
Ludviksdottir, Dora
Maitland-van der Zee, Anke Hilse
Menzies-Gow, Andrew
Murray, Ruth B.
Papadopoulos, Nikolaos G.
Perez-de-Llano, Luis
Peters, Matthew
Pfeffer, Paul E.
Popov, Todor A.
Porsbjerg, Celeste M.
Price, Chris A.
Rhee, Chin K.
Sadatsafavi, Mohsen
Tohda, Yuji
Eileen, Wang
Wechsler, Michael E.
Zangrilli, James
Price, David

August 2020

Acknowledgements The authors thank the following individuals who contributed to the initial set-up o...

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Mikus M. S.
Kolmert J.
Andersson L. I.
Ostling J.
Knowles R. G.
Gomez C.
Ericsson M.
Thorngren J. -O.
Khoonsari P. E.
Dahlen B.
Kupczyk M.
de Meulder B.
Auffray C.
Bakke P. S.
Beghe Bianca
Bel E. H.
Caruso M.
Chanez P.
Chawes B.
Fowler S. J.
Gaga M.
Geiser T.
Gjomarkaj M.
Horvath I.
Howarth P. H.
Johnston S. L.
Joos G.
Krug N.
Montuschi P.
Musial J.
Nizankowska-Mogilnicka E.
Olsson H. K.
Papi A.
Rabe K. F.
Sandstrom T.
Shaw D. E.
Siafakas N. M.
Uhlen M.
Riley J. H.
Bates S.
Middelveld R. J. M.
Wheelock C. E.
Chung K. F.
Adcock I. M.
Sterk P. J.
Djukanovic R.
Nilsson P.
Dahlen S. -E.
James A.
Ahmed H.
Balgoma D.
Bansal A. T.
Baribaud F.
Bigler J.
Billing B.
Bisgaard H.
Boedigheimer M. J.
Bonnelykke K.
Brandsma J.
Brinkman P.
Bucchioni E.
Burg D.
Bush A.
Chaiboonchoe A.
Checa T.
Compton C. H.
Corfield J.
Cunoosamy D.
D'Amico A.
Emma R.
Erpenbeck V. J.
Erzen D.
Fichtner K.
Fitch N.
Fleming L. J.
Formaggio E.
Frey U.
Gahlemann M.
Goss V.
Guo Y. -K.
Hashimoto S.
Haughney J.
Hedlin G.
Hekking P. -P. W.
Higenbottam T.
Hohlfeld J. M.
Holweg C. T. J.
Knox A. J.
Konradsen J.
Lazarinis N.
Lefaudeux D.
Li T.
Loza M. J.
Lutter R.
Manta A.
Masefield S.
Matthews J. G.
Mazein A.
Meiser A.
Miralpeix M.
Mores N.
Murray C. S.
Myles D.
Naz S.
Nordlund B.
Pahus L.
Pandis I.
Pavlidis S.
Postle A.
Powel P.
Rao N.
Reinke S.
Roberts A.
Roberts G.
Rowe A.
Schofield J. P. R.
Seibold W.
Selby A.
Sigmund R.
Singer F.
Sjodin M.
Skipp P. J.
Sousa A. R.
Sun K.
Thornton B.
Uddin M.
van Aalderen W. M.
van Geest M.
Vestbo J.
Vissing N. H.
Wagener A. H.
Wagers S. S.
Weiszhart Z.
Wheelock C. E.
Wheelock A.
Wilson S. J.
Yasinska V.
Brusselle G. G.
Campbell D. A.
Contoli M.
Damm K.
de Rudder I.
Delin I.
Devautour C.
Duplaga M.
Eduards M.
Ek A.
Ekstrom T.
Figiel E.
Gaber F.
Gauw S.
Gawlewicz-Mroczka A.
Gerding D.
Haque S.
Hewitt L.
Hiemstra P. S.
Holgate S. T.
Holloway J.
Kania A.
Kanniess F.
Karlsson O.
Kips J. C.
Kumlin M.
Lantz A. -S.
Lazarinis N.
Magnussen H.
Mallia P.
Martling I.
Meziane L.
Oikonomidou E.
Olsson M.
Pace E.
Papadopouli E.
Papadopoulos N.
Plataki M.
Profita M.
Reinius L. E.
Richter K.
Robinson D. S.
Romagnoli M.
Samara K.
Schelfhout V.
Skedinger M.
Stamataki E.
ten Brinke A.
Vachier I.
Wallen-Nielsen E.
van Veen I.
Weersink E.
Wilson S. J.
Yasinska V.
Zervas E.
Ziolkowska-Graca B.

January 2022

Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma bioma...

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma

Rossios, Christos
Pavlidis, Stelios
Hoda, Uruj
Kuo, Chih Hsi
Wiegman, Coen
Russell, Kirsty
Sun, Kai
Loza, Matthew J.
Baribaud, Frederic
Durham, Andrew L.
Ojo, Oluwaseun
Lutter, Rene
Rowe, Anthony
Bansal, Aruna
Auffray, Charles
Sousa, Ana
Corfield, Julie
Djukanovic, Ratko
Guo, Yike
Sterk, Peter J.
Chung, Kian Fan
Adcock, Ian M.
Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) Consortia Project Team

February 2018

Background: Sputum analysis in asthmatic patients is used to define airway inflammatory processes an...

Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

Denton, Eve
Price, David B
Tran, Trung N
Canonica, G Walter
Menzies-Gow, Andrew
FitzGerald, J Mark
Sadatsafavi, Mohsen
Perez de Llano, Luis
Christoff, George
Quinton, Anna
Rhee, Chin Kook
Brusselle, Guy
Ulrik, Charlotte
Lugogo, Njira
Hore-Lacy, Fiona
Chaudhry, Isha
Bulathsinhala, Lakmini
Murray, Ruth B
Carter, Victoria A
Hew, Mark

July 2021

Funding: ISAR is conducted by Optimum Patient Care Global Ltd, and co-funded by OPC Global Ltd and A...

Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry

Eve Denton
David B. Price
Trung N. Tran
G. Walter Canonica
Andrew N. Menzies-Gow
J. Mark FitzGerald
Mohsen Sadatsafavi
Luis Perez de Llano
George C. Christoff
Anna Quinton
Chin Kook Rhee
G.G.O. (Guy) Brusselle
Charlotte Suppli Ulrik
Njira Lugogo
Fiona Hore-Lacy
Isha Chaudhry
Lakmini Bulathsinhala
Ruth Murray
Victoria A. Carter
Mark Hew

July 2021

Background: Allergy, eosinophilic inflammation, and epithelial dysregulation are implicated in sever...

Cluster analysis of inflammatory biomarker expression in the international severe asthma registry

Denton, Eve
Price, David B.
Tran, Trung N.
Canonica, G. Walter
Menzies-Gow, Andrew
FitzGerald, J. Mark
Sadatsafavi, Mohsen
Perez de Llano, Luis
Christoff, George
Quinton, Anna
Kook Rhee, Chin
Brusselle, Guy
Ulrik, Charlotte
Lugogo, Njira
Hore-Lacy, Fiona
Chaudhry, Isha
Bulathsinhala, Lakmini
Murray, Ruth B.
Carter, Victoria A.
Hew, Mark

January 2021

Background: Allergy, eosinophilic inflammation, and epithelial dysregulation are implicated in sever...

Eosinophilic and non-eosinophilic asthma : an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort

Heaney, Liam G
Perez de Llano, Luis
Al-Ahmad, Mona
Backer, Vibeke
Busby, John
Canonica, Giorgio Walter
Christoff, George
Cosio, Borja G.
FitzGerald, J. Mark
Heffler, Enrico
Iwanaga, Takashi
Jackson, David J
Menzies-Gow, Andrew
Papadopoulos, Nikolaos G
Papaioannou, Andriana I.
Pfeffer, Paul E
Popov, Todor A
Porsbjerg, Celeste M.
Rhee, Chin Kook
Sadatsafavi, Mohsen
Tohda, Yuji
Eileen, Wang
Wechsler, Michael E
Alacqua, Marianna
Altraja, Alan
Bjermer, Leif
Björnsdóttir, Unnur S.
Bourdin, Arnaud
Brusselle, Guy
Buhl, Roland
Costello, Richard W
Hew, Mark
Siyue, Mariko Koh
Lehmann, Sverre
Lehtimäki, Lauri
Peters, Matthew
Taillé, Camille
Taube, Christian
Tran, Trung N
Tran, Trung N
Bulathsinhala, Lakmini
Carter, Victoria A
Chaudhry, Isha
Eleangovan, Nevaashni
Hosseini, Naeimeh
Kerkhof, Marjan
Murray, Ruth B
Price, Chris
Price, David

September 2021

FUNDING/SUPPORT: This study was conducted by the Observational and Pragmatic Research Institute (OPR...

Real-life biomarker response to anti-IL5 and anti-IgE therapies in severe asthma patients

Burkill, Sarah
Porsbjerg, Celeste M.
Bourdin, Arnaud
Tran, Trung N
Martin, Neil
Katial, Rohit
Barker, Peter
Wechsler, Michael E
Maspero, Jorge F
Bosnic-Anticevich, Sinthia
Chung, Li Ping
Katsoulotos, Gregory
Christoff, George
Popov, Todor A
Sadatsafavi, Mohsen
Torres-Duque, Carlos A.
Ulrik, Charlotte
Assing, Karin Dahl
Hansen, Susanne
Altraja, Alan
Lehtimäki, Lauri A.
Papadopoulos, Nikolaos G
Kostikas, Konstantinos
Salvi, Sundeep
Costello, Richard W
Puggioni, Francesca
Iwanaga, Takashi
Rhee, Chin Kook
Al-Ahmad, Mona
Larenas-Linnemann, Désirée
Fonseca, João A.
Amaral, Rita
Al-Lehebi, Riyad
Perez de Llano, Luis
Kirenga, Bruce
Tsai, Ming-Ju
Mahboub, Bassam
Pfeffer, Paul E
Henley, William
Liu, Yang
Lyu, Juntao
Goh, Celine
Uthaman, Thendral
Price, David
ISAR IGNITE

November 2023

Funding: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte L...

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

Wilson, Susan J.
Ward, Jonathan A.
Sousa, Ana
Corfield, Julie
Bansal, Aruna T.
De Meulder, Bertrand
Lefaudeux, Diane
Auffray, Charles
Loza, Matthew J.
Baribaud, Frederic
Fitch, Neil
Sterk, Peter J.
Chung, Kian
Gibeon, David
Sun, Kai
Guo, Yi-Ke
Adcock, Ian
Djukanovic, Ratko
Dahlen, Barbro
Chanez, Pascal
Shaw, Dominick
Krug, Norbert
Hohlfeld, Jens
Sandtrom, Thomas
Howarth, Peter H.
on behalf of the U-BIOPRED Study Group

November 2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma...

A clustering analysis of eosinophilic asthmatics

Nekoee Zahraei, Halehsadat
SCHLEICH, FLorence
HENKET, Monique
PAULUS, Virginie
Gerday, Sara
GUISSARD, Françoise
Donneau, Anne-Françoise
LOUIS, Renaud

May 2022

editorial reviewedIntroduction Eosinophilic asthma is well recognized asthma phenotype associated w...

Development of the International Severe Asthma Registry (ISAR) : A Modified Delphi Study

Bulathsinhala, Lakmini
Eleangovan, Nevaashni
Heaney, Liam G.
Menzies-Gow, Andrew
Gibson, Peter G.
Peters, Matthew
Hew, Mark
van Boven, Job F.M.
Lehtimäki, Lauri
van Ganse, Eric
Belhassen, Manon
Harvey, Erin S.
Perez de Llano, Luis
Maitland-van der Zee, Anke H.
Papadopoulos, Nikolaos G.
FitzGerald, J. Mark
Porsbjerg, Celeste
Canonica, G. Walter
Backer, Vibeke
Rhee, Chin Kook
Verhamme, Katia M.C.
Buhl, Roland
Cosio, Borja G.
Carter, Victoria
Price, Chris
Le, Thao
Stagno d'Alcontres, Martina
Gopalan, Gokul
Tran, Trung N.
Price, David

September 2019

This study is cofunded by Optimum Patient Care Global and AstraZeneca.Peer reviewedPostprin

Towards clinically applicable biomarkers for asthma - An EAACI position paper

Diamant, Zuzana
Vijverberg, Susanne
Alving, Kjell
Bakirtas, Arzu
Bjermer, Leif
Custovic, Adnan
Dahlen, Sven-Erik
Gaga, Mina
Gerth van Wijk, Roy
Del Giacco, Stefano
Hamelmann, Eckard
Heaney, Liam
Heffler, Enrico
Kalayci, Ömer
Kostikas, Konstantinos
Lutter, Rene
Olin, Anna-Carin
Sergejeva, Svetlana
Simpson, Angela
Sterk, Peter J
Tufvesson, Ellen
Agache, Ioana
Seys, Sven F

January 2019

Inflammation, structural and functional abnormalities within the airways are key features of asthma....

Severe asthma exists despite suppressed tissue inflammation: Findings of the U-BIOPRED study

Wilson, Susan J.
Ward, Jonathan A.
Sousa, Ana R.
Corfield, Julie
Bansal, Aruna T.
Meulder, Bertrand de
Lefaudeux, Diane
Auffray, Charles
Loza, Matthew J.
Baribaud, Frédéric
Fitch, Neil
Sterk, Peter J.
Chung, Kian Fan
Gibeon, David
Sun, Kai
Guo, Yi-Ke
Adcock, Ian M.
Djukanovic, Ratko
Dahlén, Barbro
Chanez, Pascal
Shaw, Dominick E.
Krug, Norbert
Hohlfeld, Jens
Sandström, Thomas
Howarth, Peter H.

January 2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma...

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Lefaudeux, D
De Meulder, B
Loza, Mj
Peffer, N
Rowe, A
Baribaud, F
Bansal, At
Lutter, R
Sousa, Ar
Corfield, J
Pandis, I
Bakke, Ps
Caruso, M
Chanez, P
Dahl\ue9n, Se
Fleming, Lj
Fowler, Sj
Horvath, I
Krug, N
Montuschi, Paolo (ORCID:0000-0001-5589-1750)
Sanak, M
Sandstrom, T
Shaw, De
Singer, F
Sterk, Pj
Roberts, G
Adcock, Im
Djukanovic, R
Auffray, C
Chung, Kf
BIOPRED Study Group, U.

January 2017

BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma tr...

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.

Wilson, SJ
Ward, JA
Sousa, AR
Corfield, J
Bansal, AT
De Meulder, B
Lefaudeux, D
Auffray, C
Loza, MJ
Baribaud, F
Fitch, N
Sterk, PJ
Chung, KF
Gibeon, D
Sun, K
Guo, YK
Adcock, I
Djukanovic, R
Dahlen, B
Chanez, P
Shaw, D
Krug, N
Hohlfeld, J
Sandström, T
Howarth, PH
U-BIOPRED Study Group

August 2016

The U-BIOPRED study is a multicentre European study aimed at a better understanding of severe asthma...

International severe asthma registry (ISAR) : protocol for a global registry

FitzGerald, J. Mark
Tran, Trung N.
Alacqua, Marianna
Altraja, Alan
Backer, Vibeke
Bjermer, Leif
Bjornsdottir, Unnur
Bourdin, Arnaud
Brusselle, Guy
Bulathsinhala, Lakmini
Busby, John
Canonica, Giorgio W.
Carter, Victoria
Chaudhry, Isha
Cho, You Sook
Christoff, George
Cosio, Borja G.
Costello, Richard W.
Eleangovan, Neva
Gibson, Peter G.
Heaney, Liam G.
Heffler, Enrico
Hew, Mark
Hosseini, Naeimeh
Iwanaga, Takashi
Jackson, David J.
Jones, Rupert
Koh, Mariko S.
Le, Thao
Lehtimäki, Lauri
Ludviksdottir, Dora
Maitland-van der Zee, Anke Hilse
Menzies-Gow, Andrew
Murray, Ruth B.
Papadopoulos, Nikolaos G.
Perez-de-Llano, Luis
Peters, Matthew
Pfeffer, Paul E.
Popov, Todor A.
Porsbjerg, Celeste M.
Price, Chris A.
Rhee, Chin K.
Sadatsafavi, Mohsen
Tohda, Yuji
Eileen, Wang
Wechsler, Michael E.
Zangrilli, James
Price, David

August 2020

Acknowledgements The authors thank the following individuals who contributed to the initial set-up o...

Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Mikus M. S.
Kolmert J.
Andersson L. I.
Ostling J.
Knowles R. G.
Gomez C.
Ericsson M.
Thorngren J. -O.
Khoonsari P. E.
Dahlen B.
Kupczyk M.
de Meulder B.
Auffray C.
Bakke P. S.
Beghe Bianca
Bel E. H.
Caruso M.
Chanez P.
Chawes B.
Fowler S. J.
Gaga M.
Geiser T.
Gjomarkaj M.
Horvath I.
Howarth P. H.
Johnston S. L.
Joos G.
Krug N.
Montuschi P.
Musial J.
Nizankowska-Mogilnicka E.
Olsson H. K.
Papi A.
Rabe K. F.
Sandstrom T.
Shaw D. E.
Siafakas N. M.
Uhlen M.
Riley J. H.
Bates S.
Middelveld R. J. M.
Wheelock C. E.
Chung K. F.
Adcock I. M.
Sterk P. J.
Djukanovic R.
Nilsson P.
Dahlen S. -E.
James A.
Ahmed H.
Balgoma D.
Bansal A. T.
Baribaud F.
Bigler J.
Billing B.
Bisgaard H.
Boedigheimer M. J.
Bonnelykke K.
Brandsma J.
Brinkman P.
Bucchioni E.
Burg D.
Bush A.
Chaiboonchoe A.
Checa T.
Compton C. H.
Corfield J.
Cunoosamy D.
D'Amico A.
Emma R.
Erpenbeck V. J.
Erzen D.
Fichtner K.
Fitch N.
Fleming L. J.
Formaggio E.
Frey U.
Gahlemann M.
Goss V.
Guo Y. -K.
Hashimoto S.
Haughney J.
Hedlin G.
Hekking P. -P. W.
Higenbottam T.
Hohlfeld J. M.
Holweg C. T. J.
Knox A. J.
Konradsen J.
Lazarinis N.
Lefaudeux D.
Li T.
Loza M. J.
Lutter R.
Manta A.
Masefield S.
Matthews J. G.
Mazein A.
Meiser A.
Miralpeix M.
Mores N.
Murray C. S.
Myles D.
Naz S.
Nordlund B.
Pahus L.
Pandis I.
Pavlidis S.
Postle A.
Powel P.
Rao N.
Reinke S.
Roberts A.
Roberts G.
Rowe A.
Schofield J. P. R.
Seibold W.
Selby A.
Sigmund R.
Singer F.
Sjodin M.
Skipp P. J.
Sousa A. R.
Sun K.
Thornton B.
Uddin M.
van Aalderen W. M.
van Geest M.
Vestbo J.
Vissing N. H.
Wagener A. H.
Wagers S. S.
Weiszhart Z.
Wheelock C. E.
Wheelock A.
Wilson S. J.
Yasinska V.
Brusselle G. G.
Campbell D. A.
Contoli M.
Damm K.
de Rudder I.
Delin I.
Devautour C.
Duplaga M.
Eduards M.
Ek A.
Ekstrom T.
Figiel E.
Gaber F.
Gauw S.
Gawlewicz-Mroczka A.
Gerding D.
Haque S.
Hewitt L.
Hiemstra P. S.
Holgate S. T.
Holloway J.
Kania A.
Kanniess F.
Karlsson O.
Kips J. C.
Kumlin M.
Lantz A. -S.
Lazarinis N.
Magnussen H.
Mallia P.
Martling I.
Meziane L.
Oikonomidou E.
Olsson M.
Pace E.
Papadopouli E.
Papadopoulos N.
Plataki M.
Profita M.
Reinius L. E.
Richter K.
Robinson D. S.
Romagnoli M.
Samara K.
Schelfhout V.
Skedinger M.
Stamataki E.
ten Brinke A.
Vachier I.
Wallen-Nielsen E.
van Veen I.
Weersink E.
Wilson S. J.
Yasinska V.
Zervas E.
Ziolkowska-Graca B.

January 2022

Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma bioma...

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma

Rossios, Christos
Pavlidis, Stelios
Hoda, Uruj
Kuo, Chih Hsi
Wiegman, Coen
Russell, Kirsty
Sun, Kai
Loza, Matthew J.
Baribaud, Frederic
Durham, Andrew L.
Ojo, Oluwaseun
Lutter, Rene
Rowe, Anthony
Bansal, Aruna
Auffray, Charles
Sousa, Ana
Corfield, Julie
Djukanovic, Ratko
Guo, Yike
Sterk, Peter J.
Chung, Kian Fan
Adcock, Ian M.
Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes (U-BIOPRED) Consortia Project Team

February 2018

Background: Sputum analysis in asthmatic patients is used to define airway inflammatory processes an...

Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

Abstract

Extracted data

Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

Abstract

Extracted data

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