In this paper, a preference-based, interactive memetic random-key genetic algorithm (PIMRKGA) is developed and used to find (weakly) Pareto optimal solutions to manufacturing and production problems that can be modelled as a symmetric multi-objective travelling salesman problem. Since there are a large number of solutions to these kinds of problems, to reduce the computational effort and to provide more desirable and meaningful solutions to the decision maker, this research focuses on using interactive input from the user to explore the most desirable parts of the efficient frontier instead of trying to reproduce the entire frontier. Here, users define their preferences by selecting among five classes of objective functions and by specifyin...