Add to ORKGThe compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
<div><p>Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobu...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87109/1/j.1365-2567.2011.03474.x.pd
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation,...
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen ...
Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns ...
Background: KIR2DS4 gene variants encode full-length and truncated protein products, with only the f...
Epidemiological studies have shown the protective effect of KIR3DL1/HLA-Bw4 genotypes in human immun...
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci a...
Background: Killer-cell Immunoglobulin-like Receptors(KIR) interact with Human Leukocyte Antigen(HLA...
NK cell receptors and HLA molecules are intimately involved in the immune response against viral inf...
<p>Flow chart illustrating the dual protection conferred by <i>KIR3DS1</i>/<i>Bw4-80I</i> in the nat...
Abstract The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentia...
HIV–1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KI...
Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like...
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
<div><p>Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobu...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87109/1/j.1365-2567.2011.03474.x.pd
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation,...
Multiple epidemiological studies have demonstrated associations between the human leukocyte antigen ...
Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns ...
Background: KIR2DS4 gene variants encode full-length and truncated protein products, with only the f...
Epidemiological studies have shown the protective effect of KIR3DL1/HLA-Bw4 genotypes in human immun...
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci a...
Background: Killer-cell Immunoglobulin-like Receptors(KIR) interact with Human Leukocyte Antigen(HLA...
NK cell receptors and HLA molecules are intimately involved in the immune response against viral inf...
<p>Flow chart illustrating the dual protection conferred by <i>KIR3DS1</i>/<i>Bw4-80I</i> in the nat...
Abstract The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentia...
HIV–1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KI...
Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like...
In West Africa, the Acquired Immunodeficiency Syndrome (AIDS) is caused by both types of Human Immun...
<div><p>Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobu...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87109/1/j.1365-2567.2011.03474.x.pd