Part I, Tetrasubstituted allenyl ethers: Part II, Triply convergent cyclopentannelation

Thesis (M.S.)--University of Hawaii at Manoa, 2006.Includes bibliographical references.xiv, 99 leaves, bound ill. 29 cmPart I: A method for the synthesis of tetrasubstituted allene ethers is described. The Brook rearrangement is employed to form key propargyl ether intermediates. The resulting propargyl ethers are isomerized to allenes. The allenes are used in the cyclopentannelation reaction to form β, β-disubstituted cyclopentenones. Part II: Based on methodology developed by our group, the scope of the triply convergent cyc1openmnnelation is expanded. Modifications to the existing protocol are described. An expanded set of morpholino enamides are employed