Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from glioma patient tumors. We provide detailed steps for organoid culture, intracranial implantation, and detection of tumors in the brain. We further present technical adjustments for standardized functional assays and drug testing
The lack of relevant in vitro neural models is an important obstacle on medical progress for neuropa...
There is an urgency for identifying effective therapies for glioblastoma (GBM), an incurable and let...
SummaryFrequent discrepancies between preclinical and clinical results of anticancer agents demand a...
Summary: Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valu...
Patient-derived cancer models are essential tools for studying tumor biology and preclinical interve...
peer reviewedPatient-based cancer models are essential tools for studying tumor biology and for the ...
Glioblastoma, a grade IV astrocytoma, is regarded as the most aggressive primary brain tumour with a...
Preclinical models of cancer are essential for a basic understanding of cancer biology and its trans...
Summary: We have developed a cancer model of gliomas in human cerebral organoids that allows direct ...
Glioblastoma (GB) is the most frequent and aggressive type of glioma. The lack of reliable GB models...
Developing reliable experimental models that can predict clinical response before treating the patie...
Despite substantial effort and resources dedicated to drug discovery and development, new anticancer...
The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues ...
Background: The incidence of brain metastasis appears to be increasing, potentially due to advanced ...
The lack of relevant in vitro neural models is an important obstacle on medical progress for neuropa...
The lack of relevant in vitro neural models is an important obstacle on medical progress for neuropa...
There is an urgency for identifying effective therapies for glioblastoma (GBM), an incurable and let...
SummaryFrequent discrepancies between preclinical and clinical results of anticancer agents demand a...
Summary: Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valu...
Patient-derived cancer models are essential tools for studying tumor biology and preclinical interve...
peer reviewedPatient-based cancer models are essential tools for studying tumor biology and for the ...
Glioblastoma, a grade IV astrocytoma, is regarded as the most aggressive primary brain tumour with a...
Preclinical models of cancer are essential for a basic understanding of cancer biology and its trans...
Summary: We have developed a cancer model of gliomas in human cerebral organoids that allows direct ...
Glioblastoma (GB) is the most frequent and aggressive type of glioma. The lack of reliable GB models...
Developing reliable experimental models that can predict clinical response before treating the patie...
Despite substantial effort and resources dedicated to drug discovery and development, new anticancer...
The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues ...
Background: The incidence of brain metastasis appears to be increasing, potentially due to advanced ...
The lack of relevant in vitro neural models is an important obstacle on medical progress for neuropa...
The lack of relevant in vitro neural models is an important obstacle on medical progress for neuropa...
There is an urgency for identifying effective therapies for glioblastoma (GBM), an incurable and let...
SummaryFrequent discrepancies between preclinical and clinical results of anticancer agents demand a...
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