Add to ORKGArginine is added to commercially available recombinant tissue plasminogen activator (rtPA) to promote its solubility. However, arginine is also known to inhibit certain proteases. To explore the possibility that arginine inhibits the highly concentrated rtPA in commercial formulations, we tested the amino acid in assays of tPA function. Although arginine was found to inhibit rtPA cleavage of a chromogenic substrate, it did not interfere with rtPA-mediated fibrinolysis. Nor did it inhibit plasmin activity. However, the coagulant proteases thrombin and Factor Xa were inhibited by arginine. Therefore, the concentration of arginine in commercial preparations of rtPA appears to have an anticoagulant activity but does not retard fibrinolysis.Hon...
It has been shown that the most important inhibitor of plasmin is alpha 2-antiplasmin, however, othe...
Open access articleThe inhibition of arginase, resulting in higher arginine (ARG) availability for n...
Alpha-2-antiplasmin, a major inhibitor of fibrinolysis, is synthesized in the liver and occurs in bl...
Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombol...
Fibrinolytic factors were assessed during L‐asparaginase administration, to study whether their chan...
AbstractThe goal of the study was to assess if aprotinin, a protease inhibitor, could be used to ant...
This article is licensed under a Creative Commons Attribution 4.0 International License, which permi...
The purpose of this study was to characterize the inhibitory effects of choline on the terminal enzy...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Post-translational modification (PTM) of platelet proteins has long been known to have an effect on ...
According to present concepts, the enzyme responsible for the dissolution of fibrin both intra - and...
Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine resid...
Jane Hoover-PlowJoseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Cardiovas...
Oxidative stress plays a prominent role in the development of endothelial dysfunction. L-arginine an...
Pseudomonas aeruginosa is a Gram- negative bacteria that is the leading cause of mortality in immuno...
It has been shown that the most important inhibitor of plasmin is alpha 2-antiplasmin, however, othe...
Open access articleThe inhibition of arginase, resulting in higher arginine (ARG) availability for n...
Alpha-2-antiplasmin, a major inhibitor of fibrinolysis, is synthesized in the liver and occurs in bl...
Alteplase is the only drug licensed for acute ischemic stroke, and in this formulation, the thrombol...
Fibrinolytic factors were assessed during L‐asparaginase administration, to study whether their chan...
AbstractThe goal of the study was to assess if aprotinin, a protease inhibitor, could be used to ant...
This article is licensed under a Creative Commons Attribution 4.0 International License, which permi...
The purpose of this study was to characterize the inhibitory effects of choline on the terminal enzy...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Post-translational modification (PTM) of platelet proteins has long been known to have an effect on ...
According to present concepts, the enzyme responsible for the dissolution of fibrin both intra - and...
Protein arginine methyltransferases (PRMTs) catalyze the transfer of methyl groups to arginine resid...
Jane Hoover-PlowJoseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Cardiovas...
Oxidative stress plays a prominent role in the development of endothelial dysfunction. L-arginine an...
Pseudomonas aeruginosa is a Gram- negative bacteria that is the leading cause of mortality in immuno...
It has been shown that the most important inhibitor of plasmin is alpha 2-antiplasmin, however, othe...
Open access articleThe inhibition of arginase, resulting in higher arginine (ARG) availability for n...
Alpha-2-antiplasmin, a major inhibitor of fibrinolysis, is synthesized in the liver and occurs in bl...