[Hemolytic-uremic syndrome: what is the mechanism?]

Many data suggest that improper regulation of the alternative complement pathway is involved in the pathophysiology of atypical hemolytic-uremic syndrome. Until a few years ago, research exclusively focused on protein assays, which did not help to identify precise genetic factors predisposing to atypical hemolytic-uremic syndrome. In this context, the introduction of gene study considerably accelerated advances