Cyclodextrin based pseudopolyrotaxanes and polyrotaxanes for biological applications

Due to their controllable size, low cytotoxicity, and unique architecture, cyclodextrin based polyrotaxanes and pseudopolyrotaxanes have been developed to encompass a broad range of diverse medical applications from erodable hydrogels to drug and gene delivery. This review summarizes the synthesis, characterization, dynamics, applications, and potential utility of cyclodextrin based polyrotaxanes and pseudopolyrotaxanes for medical applications. Specifically, this chapter reviews the literature appearing on this topic between 1999 and November 2006