The main goal of this dissertation is to explore the nature of contrast in sign language handshapes. I first demonstrate that the distribution of handshape contrasts is not homogeneous, either within or across sign languages. By using a variety of methodologies (examination of dictionary data, elicited data, and psycholinguistic experimentation), I present examples of differences related to type of contrast (distinctive, active, and prominent—following Clements, 2001); position in the lexical substrata (following the work of Ito and Mester, 1995a, and Brentari and Padden, 2001); iconic relationships (e.g. shape, size, arrangement of parts); and cross-linguistic variation (comparing American Sign Language, Swiss German Sign Language, and Hon...