Aerosols in the lung: multi-domain transport and coupling

International audienceIn this paper, we present a framework that couples three-dimensional (3D) to one-dimensional (1D) transport models to predict particle deposition in the respiratory airways throughout respiration. During respiration, the time dependent flow rate and particle concentration can be passed between the domains (inspiration: 3D to 1D, expiration: 1D to 3D). This framework enables us to predict particle transport and deposition in the whole lung and throughout both inspiration and expiration