Neuroanatomical basis of paroxysmal sympathetic hyperactivity: a diffusion tensor imaging analysis
- Hinson, Holly E
- Puybasset, Louis
- Weiss, Nicolas
- Perlbarg, Vincent
- Benali, Habib
- Galanaud, Damien
- Lasarev, Mike
- Stevens, Robert D
DOIAbstract
International audienceParoxysmal sympathetic hyperactivity (PSH) is observed in a sub-set of patients with moderate-to-severe traumatic brain injury (TBI). The neuroanatomical basis of PSH is poorly understood. It is hypothesized that PSH is linked to changes in connectivity within the central autonomic network. Retrospective analysis in a sub-set of patients from a multi-centre, prospective cohort study Methods and procedures: Adult patients who were <3 weeks after severe TBI were enrolled and screened for PSH using a standard definition. Patients underwent multimodal MRI, which included quantitative diffusion tensor imaging. Principal component analysis (PCA) was used to resolve the set of tracts into components. Ability to predict PSH wa...
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