Effect of workflow metrics on clinical outcomes of low diffusion-weighted imaging Alberta Stroke Program Early Computed Tomography Score (DWI-ASPECTS) patients subjected to mechanical thrombectomy

International audienceBackground although accumulating evidence has demonstrated the benefit of mechanical thrombectomy (MT) in patients with low alberta stroke Program early computed Tomography score (asPecTs), it is still unclear how workflow metrics impact the clinical outcomes of this subgroup of patients. Methods Patients with acute stroke and diffusionweighted imaging (DWi) asPecTs ≤5 at baseline, who underwent MT within 6 hours of symptoms onset, were included from a prospectively maintained national multicentric registry between January 1, 2012 to august 31, 2017. The degree of disability was assessed by the modified rankin scale (mrs) at 90 days. The primary outcome was functional independence defined as mrs 0 to 2 at 90 days. Results The study included 291 patients with baseline DWi-asPecTs ≤5. good outcome was achieved in 82 (28.2%) patients, and 104 (35.7%) patients died within 90 days. successful reperfusion (modified Thrombolysis in cerebral infarction (mTici) 2b-3) rate was 75.3%, and median onset to recanalization (OTr) time was 2 268min. among time-related variables, OTr emerged as the strongest predictor of primary outcome (adjusted Or for every 60 min 0.59, 95% ci 0.44 to 0.77; p