International audienceThe present book mainly refers to the macroscopic scale, although nano- and microscale pathophysiological mechanisms are described. It includes 9~chapters. Chapters~1 and~2 describe the context, factors, and processes involved in pathogenesis of cardiac diseases. Chapter~3 is devoted to adverse cardiac remodeling, that is, fibrosis and hypertrophy, Chap.~4 to cardiomyopathies, Chap.~5. to rhythm and conduction alterations, Chap.~6. to cardiac valve diseases, Chap.~7 to heart failure, Chap.~8. to coronary artery disease and myocardial infarction, and Chap.~9 to interventional medicine and surgery of cardiac diseases