Effects of simulated error-sources on different 3-D CSI-EPT strategies

Three-dimensional contrast source inversion-electrical properties tomography (3-D CSI-EPT) is an iterative reconstruction method that estimates the electrical properties of tissue from transmit field magnetic resonance data. However, in order to bring 3-D CSI-EPT into practice for complex tissue structures and to understand the origin and effect of errors, insight in the sensitivities of reconstruction accuracy to the major error-sources is necessary. In this paper, different strategies for implementing 3-D CSI-EPT, including their iterative structure, are presented, of which the regularized implementation shows the most potential to be used in practice. Moreover, the influence of initialization, noise, stopping criteria, incident fields, B1-maps, transceive phase and domain truncation are discussed. We show that of all these different error-sources, initialization, accurate coil models and domain truncation have the most dramatic effect on electrical properties reconstructions in practice.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas