Background Molecular lymph node workup with one-step nucleic acid amplification (OSNA) is a validated diagnostic adjunct in breast cancer and also appealing for colon cancer (CC) staging. This study, for the first time, evaluates the prognostic value of OSNA in CC. Patients and methods The retrospective study includes patients with stage I-III CC from three centres. Lymph nodes were investigated with haematoxylin and eosin (H&E) and with OSNA, applying a 250 copies/mu L threshold of CK19 mRNA. Diagnostic value of H&E and OSNA was assessed by survival analysis, sensitivity, specificity and time-dependent receiver operating characteristic curves. Results Eighty-seven patients were included [mean follow-up 53.4 months (+/- 24.9)]. Disease recu...
Stage II colorectal cancer (CRC) recurrence remains a clinical problem. Some of these patients are t...
Molecular lymph node (LN) staging in early colorectal cancer (CRC) has demonstrated to be more preci...
International audienceBackground - In head and neck squamous cell carcinoma (HNSCC) 30% of cN0 patie...
Molecular lymph node workup with one-step nucleic acid amplification (OSNA) is a validated diagnosti...
BACKGROUND: A new diagnostic system, called one-step nucleic acid amplification (OSNA), has recently...
Background: Current histopathological staging procedures in colon carcinomas depend on midline divis...
Objective: Small nodal tumor infiltrates are identified by applying multilevel sectioning and immuno...
Cytokeratin 19; Prostate cancer; Lymph node metastasesCitoqueratina 19; Cáncer de próstata; Metástas...
Background: The presence of lymph node (LN) metastasis is a critical prognostic factor in colorectal...
Purpose: Analysis of the sentinel lymph node (SLN) in colorectal cancer (CRC) patients was proposed ...
Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer...
Background Pathologic lymph node staging is becoming a deficient method in the demanding molecular e...
Early-stage colorectal carcinoma (CRC)—pT1—is a therapeutic challenge and presents some histological...
One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity an...
BACKGROUND: This study aimed to determine the relationship between CK19 mRNA copy number in sentine...
Stage II colorectal cancer (CRC) recurrence remains a clinical problem. Some of these patients are t...
Molecular lymph node (LN) staging in early colorectal cancer (CRC) has demonstrated to be more preci...
International audienceBackground - In head and neck squamous cell carcinoma (HNSCC) 30% of cN0 patie...
Molecular lymph node workup with one-step nucleic acid amplification (OSNA) is a validated diagnosti...
BACKGROUND: A new diagnostic system, called one-step nucleic acid amplification (OSNA), has recently...
Background: Current histopathological staging procedures in colon carcinomas depend on midline divis...
Objective: Small nodal tumor infiltrates are identified by applying multilevel sectioning and immuno...
Cytokeratin 19; Prostate cancer; Lymph node metastasesCitoqueratina 19; Cáncer de próstata; Metástas...
Background: The presence of lymph node (LN) metastasis is a critical prognostic factor in colorectal...
Purpose: Analysis of the sentinel lymph node (SLN) in colorectal cancer (CRC) patients was proposed ...
Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer...
Background Pathologic lymph node staging is becoming a deficient method in the demanding molecular e...
Early-stage colorectal carcinoma (CRC)—pT1—is a therapeutic challenge and presents some histological...
One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity an...
BACKGROUND: This study aimed to determine the relationship between CK19 mRNA copy number in sentine...
Stage II colorectal cancer (CRC) recurrence remains a clinical problem. Some of these patients are t...
Molecular lymph node (LN) staging in early colorectal cancer (CRC) has demonstrated to be more preci...
International audienceBackground - In head and neck squamous cell carcinoma (HNSCC) 30% of cN0 patie...