Alkaloids 8-Hydroxyquinoline derivatives: Synthesis and biological activities

In this work, six new alkaloids have been synthesized from 8-hydroxyquinoline, the other part is to realize the biological activities of these compounds such as antibacterial activity, antifungal activity and cytotoxicity. The antibacterial activity was carried out by the method of diffusion in agar against: Streptococcus faecalis, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The antifungal activity was carried out by the method of diffusion in agar against: Botrytis cinerea, Fusarium oxysporum and Verticillium albo atrum, and cytotoxicity activity was achieved a larvae Artemia salina (Brine shrimp). The overall results show that the new alkaloids compounds exhibit remarkable biological activity