Background: The anthracycline doxorubicin (DOX) is an effective chemotherapeutic agent used to treat pediatric cancers, but is associated with cardiotoxicity which can manifest many years after the initial exposure. To date, very little is known about the mechanism of this late onset cardiotoxicity. Methods and Results: To understand this problem, we developed a pediatric model of late onset DOX-induced cardiotoxicity, where juvenile mice were exposed to DOX, using a cumulative dose that did not induce acute cardiotoxicity. These mice developed normally and had no obvious cardiac abnormalities as adults. However, evaluation of the vasculature revealed that juvenile DOX exposure impaired vascular development resulting in abnormal vascular ar...
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types of...
Anthracyclines are highly efficacious antineoplastic agents but they become cardiotoxic after repeat...
Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of...
Background—The anthracycline doxorubicin is an effective chemotherapeutic agent used to treat pediat...
Anthracyclines are cardiotoxic; however, there are limited data characterizing the serial changes in...
Background—Anthracyclines are the most effective drugs available in the treatment of neoplastic dise...
Aims Doxorubicin (DOX) is a widely used and effective anti-cancer therapeutic. DOX treatment is ass...
Abstract Background Anthracycline chemotherapy is an effective and widely used treatment for solid t...
Children surviving cancer and chemotherapy are at risk for adverse health events including heart fai...
The production of reactive species is a core of the redox cycling profile of anthracyclines. However...
AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acut...
Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer survivors, and...
Background: The molecular and cellular mechanisms corresponding to the compensatory and maladaptive ...
Anthracyclines are key chemotherapeutic agents used in various adult and pediatric cancers, however,...
PURPOSE: The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this...
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types of...
Anthracyclines are highly efficacious antineoplastic agents but they become cardiotoxic after repeat...
Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of...
Background—The anthracycline doxorubicin is an effective chemotherapeutic agent used to treat pediat...
Anthracyclines are cardiotoxic; however, there are limited data characterizing the serial changes in...
Background—Anthracyclines are the most effective drugs available in the treatment of neoplastic dise...
Aims Doxorubicin (DOX) is a widely used and effective anti-cancer therapeutic. DOX treatment is ass...
Abstract Background Anthracycline chemotherapy is an effective and widely used treatment for solid t...
Children surviving cancer and chemotherapy are at risk for adverse health events including heart fai...
The production of reactive species is a core of the redox cycling profile of anthracyclines. However...
AIMS: Doxorubicin (DOX) is an effective anti-cancer therapeutic, but is associated with both acut...
Anthracycline cardiotoxicity remains a serious problem in paediatric and adult cancer survivors, and...
Background: The molecular and cellular mechanisms corresponding to the compensatory and maladaptive ...
Anthracyclines are key chemotherapeutic agents used in various adult and pediatric cancers, however,...
PURPOSE: The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this...
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types of...
Anthracyclines are highly efficacious antineoplastic agents but they become cardiotoxic after repeat...
Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of...