Incidentally detected asymptomatic HBV positive subjects with slightly raised liver alanine amino transferase (alt).

Introduction: One third of world population (Two billion people) has been infected with hepatitis B virus. It is one of the most common infectious diseases among the world’s leading cause of death. HBV induced chronic liver disease is also an important precursor for the development of hepatocellular carcinoma even in absence of cirrhosis. Many subjects are un aware of viruses that are the cause of hepatitis except when they have been fully involved by the disease and it has become apparent with significant signs and symptoms. Objective: To discuss raised liver Alanine amino transferase (ALT) activity in asymptomatic HBV positive subjects. Methodology: This study was carried out at pathology laboratory Muhammad Medical College Mirpurkhas from January 2015 to July 2016. Total125 hepatitis B positive asymptomatic subjects were selected and screened out as routine laboratory investigations. Results:  Selected asymptomatic subjects showed normal Reference levels for TB, ALK and GGT. While ALT was raised above reference range.Conclusion: To give awareness regarding the appropriate measures to reduce the risk in subjects which are asymptomatic and unaware of liver viruses with slightly raised enzyme activity.  Key Words: HBV, ALT, Hepatiti