Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for which the biological mechanisms remain largely unknown. Systems genetics is a powerful method for discovering novel mechanisms underlying complex traits, and intravenous drug self-administration (IVSA) is the gold standard for assessing volitional drug use in preclinical studies. We have integrated these approaches to identify novel genes and networks underlying cocaine use in mice. Methods: Mice from 39 BXD strains acquired cocaine IVSA (0.56 mg/kg/infusion). Mice from 29 BXD strains completed a full dose-response curve (0.032-1.8 mg/kg/infusion). We identified independent genetic correlations between cocaine IVSA and measures of environmenta...
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United Sta...
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societ...
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societ...
Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
Cocaine addiction is a global public health issue that affects millions of people worldwide. Like ot...
Cocaine self-administration is a complexly determined trait, with a substantial proportion of indivi...
Animal models of drug use have investigated possible mechanisms governing human substance use traits...
RATIONALE: Few effective treatments exist for cocaine use disorders due to gaps in knowledge about i...
RATIONALE: The preference for and reaction to novelty are strongly associated with addiction to coca...
RATIONALE: The preference for and reaction to novelty are strongly associated with addiction to coca...
RATIONALE: The preference for and reaction to novelty are strongly associated with addiction to coca...
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United Sta...
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United Sta...
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societ...
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societ...
Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
Rationale: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
RATIONALE: Cocaine addiction is a major public health problem with a substantial genetic basis for w...
Cocaine addiction is a global public health issue that affects millions of people worldwide. Like ot...
Cocaine self-administration is a complexly determined trait, with a substantial proportion of indivi...
Animal models of drug use have investigated possible mechanisms governing human substance use traits...
RATIONALE: Few effective treatments exist for cocaine use disorders due to gaps in knowledge about i...
RATIONALE: The preference for and reaction to novelty are strongly associated with addiction to coca...
RATIONALE: The preference for and reaction to novelty are strongly associated with addiction to coca...
RATIONALE: The preference for and reaction to novelty are strongly associated with addiction to coca...
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United Sta...
Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United Sta...
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societ...
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societ...