Movement Disorders: Genetics and Models: Second Edition

The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an ancillary website with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinsons disease, Huntingtons disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. Introduces the scientific foundations for modern movement disorders research. Contributing authors are internationally known experts. Completely revised with 20% new material. Provides a comprehensive discussion of genetics for each type of movement disorder. Covers Parkinsons disease, Huntingtons disease, dystonia, tremors, and tics. Supported by a video library of movement disorders in patients with associated animal models hosted on a companion website. 2015 Elsevier Inc. All rights reserved