Synthesis of methoxy and hydroxy containing tetralones: Versatile intermediates for the preparation of biologically relevant molecules
- Ghatak, Anjan
- Dorsey, James M.
- Garner, Charles M.
- Pinney, Kevin G.
DOIAbstract
The synthesis of 5-hydroxy-6-methoxy-1-tetralone and the 7-hydroxy regioisomer along with the corresponding 5,7-dihyroxy analog has been achieved using an efficient directed metallation procedure followed by a regioselective methylene oxidation. This methodology represents a general synthetic route for the preparation of highly oxygenated tetralone analogs which are versatile building blocks for the construction of molecules of biological interest. © 2003 Elsevier Science Ltd. All rights reserved
Add to ORKG-78-and-56-dimethyl-2-(2-hydroxyisopropyl)-tetralins){kind=link}