Heart failure (HF) is known as the final manifestation of cardiovascular diseases. Although cellular heterogeneity of the heart is well understood, the phenotypic transformation of cardiac cells in progress of HF remains obscure. This study aimed to analyze phenotypic transformation of cardiac cells in HF through human single-cell RNA transcriptome profile. Here, phenotypic transformation of cardiomyocytes (CMs), endothelial cells (ECs), and fibroblasts was identified by data analysis and animal experiments. Abnormal myosin subunits including the decrease in Myosin Heavy Chain 6, Myosin Light Chain 7 and the increase in Myosin Heavy Chain 7 were found in CMs. Two disease phenotypes of ECs named inflammatory ECs and muscularized ECs were ide...
Objective: To investigate the global changes accompanying human dilated cardiomyopathy (DCM) we perf...
Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal ...
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopat...
Heart failure is a clinical syndrom and leading cause of death worldwide, caused by functional and s...
INTRODUCTION Human heart failure is a highly morbid condition that affects 23 million individuals wo...
Summary: The heart is the central organ of the circulatory system, and its proper development is vit...
BACKGROUND: Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including hear...
Abstract Background Current heart failure (HF) treatment is based on targeting symptoms and left ven...
The heart, which is the first organ to develop, is highly dependent on its form to function. Disrupt...
The efficiency of the repair process following ischemic cardiac injury is a crucial determinant for ...
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing...
Cardiac disease causes 33% of deaths worldwide but our knowledge of disease progression is still ver...
Heart failure is a complex syndrome characterized by the inability of the heart to pump enough blood...
Purpose: Mesenchymal stem cells (MSC) are pluripotent cells which are known to reside in a number of...
OBJECTIVES: Clinically, patients with chronic heart failure arising from different etiologies receiv...
Objective: To investigate the global changes accompanying human dilated cardiomyopathy (DCM) we perf...
Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal ...
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopat...
Heart failure is a clinical syndrom and leading cause of death worldwide, caused by functional and s...
INTRODUCTION Human heart failure is a highly morbid condition that affects 23 million individuals wo...
Summary: The heart is the central organ of the circulatory system, and its proper development is vit...
BACKGROUND: Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including hear...
Abstract Background Current heart failure (HF) treatment is based on targeting symptoms and left ven...
The heart, which is the first organ to develop, is highly dependent on its form to function. Disrupt...
The efficiency of the repair process following ischemic cardiac injury is a crucial determinant for ...
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing...
Cardiac disease causes 33% of deaths worldwide but our knowledge of disease progression is still ver...
Heart failure is a complex syndrome characterized by the inability of the heart to pump enough blood...
Purpose: Mesenchymal stem cells (MSC) are pluripotent cells which are known to reside in a number of...
OBJECTIVES: Clinically, patients with chronic heart failure arising from different etiologies receiv...
Objective: To investigate the global changes accompanying human dilated cardiomyopathy (DCM) we perf...
Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal ...
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopat...