Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells. ASIC1a is expressed in astrocytes and might contribute to synaptic transmission and long-term potentiation. In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. Under pathological conditions, ASIC dysregulation in glial cells can contribute to disease state...
Acid-sensing ion channels (ASICs), newly discoveredmembers of epithelial Na+ channels/degenirin supe...
Acid-sensing ion channels (ASICs) are activated by an increase in the extracellular proton concentra...
Acid-sensing ion channels (ASICs), newly discovered members of epithelial Na+ channels/degenirin sup...
Peripheral and central immune cells are critical for fighting disease, but they can also play a pivo...
Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and s...
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. The...
Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration. The neuronall...
Abstract Extracellular acidification occurs in the brain with elevated neural activity, increased me...
NG2 cells, a fourth type of glial cell in the mammalian CNS, undergo reactive changes in response to...
A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions suc...
Acid Sensing Ion Channel (ASICs) are proton-gated channels involved in multiple biological functions...
ASIC subunit ratio and differential surface trafficking in the brain Junjun Wu1,2, Yuanyuan Xu1,3, Y...
Acid-sensing ion channel (ASIC) 1a subunit is expressed in synapses of central neurons where it cont...
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are ...
Proton receptors of the acid-sensing ion channel (ASIC) family are expressed in sensory neurons and ...
Acid-sensing ion channels (ASICs), newly discoveredmembers of epithelial Na+ channels/degenirin supe...
Acid-sensing ion channels (ASICs) are activated by an increase in the extracellular proton concentra...
Acid-sensing ion channels (ASICs), newly discovered members of epithelial Na+ channels/degenirin sup...
Peripheral and central immune cells are critical for fighting disease, but they can also play a pivo...
Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and s...
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. The...
Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration. The neuronall...
Abstract Extracellular acidification occurs in the brain with elevated neural activity, increased me...
NG2 cells, a fourth type of glial cell in the mammalian CNS, undergo reactive changes in response to...
A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions suc...
Acid Sensing Ion Channel (ASICs) are proton-gated channels involved in multiple biological functions...
ASIC subunit ratio and differential surface trafficking in the brain Junjun Wu1,2, Yuanyuan Xu1,3, Y...
Acid-sensing ion channel (ASIC) 1a subunit is expressed in synapses of central neurons where it cont...
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are ...
Proton receptors of the acid-sensing ion channel (ASIC) family are expressed in sensory neurons and ...
Acid-sensing ion channels (ASICs), newly discoveredmembers of epithelial Na+ channels/degenirin supe...
Acid-sensing ion channels (ASICs) are activated by an increase in the extracellular proton concentra...
Acid-sensing ion channels (ASICs), newly discovered members of epithelial Na+ channels/degenirin sup...