Study hypothesis: Dicoumarol (DC) has potential for use as a gonad-safe anticancer agent. study finding: DCaltered cell proliferation, decreased viability and increased apoptosis in Vero and MCF-7 cell lines but did not showany toxic effect on mouse ovarian tissues and developing oocytes in vitro and in vivo. what is known already: DCsuppresses cell proliferation and increases apoptosis in various cancer cells such as breast, urogenital and melanoma. DC has also been reported to alter the anticancer effects of several chemotherapeutics, including cisplatin, gemcitabine and doxorubicin in prostate, liver and uroepithelial cancer cells, respectively. study design, samples/materials, methods: Vero (African green monkey kidney epithelial cells)...
Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a promising an...
© 2021 Quynh-Nhu Thieu NguyenCancer survivorship has risen, but in females, DNA-damaging treatments ...
Doxorubicin (DXR) is a frontline chemotherapy agent implicated in unintended ovarian failure in fema...
Study hypothesis: Dicoumarol (DC) has potential for use as a gonad-safe anticancer agent. study find...
Survival rates from childhood cancer are improving, however chemotherapy can cause ovarian failure a...
Females are born with the total amount of ovarian eggs they will ever have, and their ovarian reserv...
As many chemotherapy regimens induce follicular depletion, fertility preservation became a major con...
Purpose: To investigate the anticancer effects of 7-hydroxycoumarin against cisplatin-resistant ovar...
Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency a...
Abstract Background Given the seriousness of chemotherapy-induced ovarian injury in female cancer pa...
Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency a...
It is still controversial that GnRH agonist (GnRHa) protects ovarian function from chemotherapy-indu...
Objective: To assess the effect of gonadotropin-releasing hormone analogue (GnRHa) on the preservat...
Study question: This work investigates whether oral administration of a natural carotenoid affects o...
<div><p>Advances in cancer treatment utilizing multiple chemotherapies have dramatically increased c...
Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a promising an...
© 2021 Quynh-Nhu Thieu NguyenCancer survivorship has risen, but in females, DNA-damaging treatments ...
Doxorubicin (DXR) is a frontline chemotherapy agent implicated in unintended ovarian failure in fema...
Study hypothesis: Dicoumarol (DC) has potential for use as a gonad-safe anticancer agent. study find...
Survival rates from childhood cancer are improving, however chemotherapy can cause ovarian failure a...
Females are born with the total amount of ovarian eggs they will ever have, and their ovarian reserv...
As many chemotherapy regimens induce follicular depletion, fertility preservation became a major con...
Purpose: To investigate the anticancer effects of 7-hydroxycoumarin against cisplatin-resistant ovar...
Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency a...
Abstract Background Given the seriousness of chemotherapy-induced ovarian injury in female cancer pa...
Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency a...
It is still controversial that GnRH agonist (GnRHa) protects ovarian function from chemotherapy-indu...
Objective: To assess the effect of gonadotropin-releasing hormone analogue (GnRHa) on the preservat...
Study question: This work investigates whether oral administration of a natural carotenoid affects o...
<div><p>Advances in cancer treatment utilizing multiple chemotherapies have dramatically increased c...
Pyruvate dehydrogenase kinase 1 (PDK1) is overexpressed in ovarian cancer and thus is a promising an...
© 2021 Quynh-Nhu Thieu NguyenCancer survivorship has risen, but in females, DNA-damaging treatments ...
Doxorubicin (DXR) is a frontline chemotherapy agent implicated in unintended ovarian failure in fema...