The goal of this paper consists of developing a new (more physical and numerical in comparison with standard and non-standard analysis approaches) point of view on Calculus with functions assuming infinite and infinitesimal values. It uses recently introduced infinite and infinitesimal numbers being in accordance with the principle ‘The part is less than the whole’ observed in the physical world around us. These numbers have a strong practical advantage with respect to traditional approaches: they are representable at a new kind of a computer – the Infinity Computer – able to work numerically with all of them. An introduction to the theory of physical and mathematical continuity and differentiation (including subdifferen...