Krüppel-associated box (KRAB) zinc finger proteins are a large class of tetrapod transcription factors that usually exert transcriptional repression through recruitment of TRIM28/KAP1. The evolutionary root of modern KRAB domains (mKRAB) can be traced back to an ancestral motif (aKRAB) that occurs even in invertebrates. Here, we first stratified three subgroups of aKRAB sequences from the animal kingdom (PRDM9, SSX and coelacanth KZNF families) and defined ancestral subdomains for KRAB-A and KRAB-B. Using human ZNF10 mKRAB-AB as blueprints for function, we then identified the necessary amino acid changes that transform the inactive aKRAB-A of human PRDM9 into an mKRAB domain capable of mediating silencing and complexing TRIM28/KAP1 in human...
Krüppel-related zinc finger proteins constitute the largest single class of transcription factors wi...
AbstractWe report the characterization of three novel members of the KRAB-domain-containing C2H2 zi...
Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcripti...
All living organisms consist of cells and the identity of a cell is defined by the genes it expresse...
Transposable elements are a genetic reservoir from which new genes and regulatory elements can emerg...
Transposable elements are a genetic reservoir from which new genes and regulatory elements can emerg...
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest indivi...
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest indivi...
Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by...
Abstract: Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the larg...
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest indivi...
Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by...
<div><p>The Krüppel-associated box (KRAB) domain interacts with the nuclear hub protein TRIM28 to in...
KRAB-associated C2H2 zinc-finger (KRAB-ZNF) proteins are the products of a rapidly evolving gene fam...
The Krüppel-associated box (KRAB) domain interacts with the nuclear hub protein TRIM28 to initiate ...
Krüppel-related zinc finger proteins constitute the largest single class of transcription factors wi...
AbstractWe report the characterization of three novel members of the KRAB-domain-containing C2H2 zi...
Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcripti...
All living organisms consist of cells and the identity of a cell is defined by the genes it expresse...
Transposable elements are a genetic reservoir from which new genes and regulatory elements can emerg...
Transposable elements are a genetic reservoir from which new genes and regulatory elements can emerg...
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest indivi...
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest indivi...
Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by...
Abstract: Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the larg...
Zinc finger proteins containing the Kruppel associated box (KRAB-ZFPs) constitute the largest indivi...
Krüppel‐associated box (KRAB)‐containing zinc finger proteins (KZFPs) are encoded in the hundreds by...
<div><p>The Krüppel-associated box (KRAB) domain interacts with the nuclear hub protein TRIM28 to in...
KRAB-associated C2H2 zinc-finger (KRAB-ZNF) proteins are the products of a rapidly evolving gene fam...
The Krüppel-associated box (KRAB) domain interacts with the nuclear hub protein TRIM28 to initiate ...
Krüppel-related zinc finger proteins constitute the largest single class of transcription factors wi...
AbstractWe report the characterization of three novel members of the KRAB-domain-containing C2H2 zi...
Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcripti...