Add to ORKGThe rheology of biological tissue plays an important role in many processes, from organ formation to cancer invasion. Here, we use a multi-phase field model of motile cells to simulate active microrheology within a tissue monolayer. When unperturbed, the tissue exhibits a transition between a solid-like state and a fluid-like state tuned by cell motility and deformability - the ratio of the energetic costs of steric cell-cell repulsion and cell surface tension. When perturbed, solid tissues exhibit yield-stress behavior, with a threshold force for the onset of motion of a probe particle that vanishes upon approaching the solid-to-liquid transition. This onset of motion is qualitatively different in the low and high deformability regimes. At...