In this article we investigate $^{40,48}$Ca+$^{40,48}$Ca peripheral and semi-peripheral reactions at 35 MeV/nucleon. Data were obtained using the unique coupling of the VAMOS high acceptance spectrometer and the INDRA charged particle multidetector.The spectrometer allowed high resolution measurement of charge, mass and velocity of the cold projectile-like fragment (PLF), while the INDRA detector recorded coincident charged particles with nearly $4\pi$ acceptance.The measured isotopic composition of the PLF identified in VAMOS and the average light charged particle (LCP) multiplicities are promising observables to study the isospin diffusion.The detection of the PLF in coincidence with LCP allows the reconstruction of the mass, charge and e...