Natural circulation is exploited in nuclear systems to passively remove power in case of accident scenarios. In this regard, the DYNASTY experimental facility at Politecnico di Milano has been setup to increase the knowledge on single-phase, buoyancy-driven systems in the presence of distributed heating. In this paper, the development of a computational fluid dynamics (CFD) model of DYNASTY is presented, focusing on the capability of CFD to assess the dynamic behavior of the facility. The large eddy simulation (LES) model takes into account both the fluid and the solid regions, with heat generation and 3D heat conduction resolved in the pipe walls. The study, conducted using OpenFOAM, shows (i) the capability of reproducing stable and unsta...