Physical exercise in a chemically and hormonally induced rat model of prostate cancer: friend or foe?

Introduction: Physical exercise is widely recognized for its beneficial health effects, namely in prostate cancer (PCa). This study aimed to evaluate the effect of physical exercise in a rat model of chemically and hormonally induced PCa.Results: Body weight was lower in exercised groups than in sedentary, either in control or in PCa groups (p0.05) and animals from PCa-exercised group showed 70.0% of dysplasia, 58.8% of PIN and 58.8% of microinvasive carcinoma (p>0.05). Conclusions: No group showed systemic signs of inflammation or clinical abnormalities. Although the prostate lesions frequencies were slightly lower in exercised PCa-induced animals than in sedentary ones, data didn ́t achieve statistical significance. However, our results suggest that physical exercise may have some preventive effect on the PCa-lesion’s development. These data deserve more investigation to clarify the effect of exercise training on prostate cancer prevention