Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.
- Sato, S.
- Dyar, K.A.
- Treebak, J.T.
- Jepsen, S.L.
- Ehrlich, A.M.
- Ashcroft, S.P.
- Trost, K.
- Kunzke, T.
- Prade, V.M.
- Small, L.
- Basse, A.L.
- Schönke, M.
- Chen, S.
- Samad, M.
- Baldi, P.
- Barrès, R.
- Walch, A.K.
- Moritz, T.
- Holst, J.J.
- Lutter, D.
- Zierath, J.R.
- Sassone-Corsi, P.
DOIAbstract
Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This...
Add to ORKG