In the human embryo, the genetic program that orchestrates germ cell specification in-volves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neo-plasias originating from fetal or neonatal germ cells, maintain such dichotomy and can adopt either pluripotent features (embryonal carcinomas) or germness features (seminomas) with a wide range of phenotypes in between these histotypes. Here, we review the basic concepts of cell specification, migration and gonadal colonization of human primordial germ cells (hPGCs) highlighting the analogies of transcriptional/epigenetic programs between these two cell types
Development of a malignant germ cell tumor, i.e., germ cell cancer (GCC) in individuals with disorde...
Germline stem cells are key to genome transmission to future generations. Over recent years, there h...
Mammalian germ cells are powerful cells, the only ones that transmit information to the next generat...
In the human embryo, the genetic program that orchestrates germ cell specification in-volves the act...
In the human embryo, the genetic program that orchestrates germ cell specification involves the acti...
In the human embryo, the genetic program that orchestrates germ cell specification in-volves the act...
The founder cells of the gametes are primordial germ cells (PGCs). In mammals, PGCs are specified ea...
SummarySpecification of primordial germ cells (PGCs) marks the beginning of the totipotent state. Ho...
Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, ...
Human germ cell development is regulated in a spatio-temporal manner by complex regulatory network...
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation hu...
Primordial germ cells (PGC) are the precursor of the gametes, which safeguard the transmission of ge...
In most multicellular organisms, including mammals, germ cells are at the origin of new organisms an...
SummaryWe recently elucidated the mechanism of human primordial germ cell (hPGC) specification and r...
Primordial germ cells (PGCs) have long been considered the link between one generation and the next....
Development of a malignant germ cell tumor, i.e., germ cell cancer (GCC) in individuals with disorde...
Germline stem cells are key to genome transmission to future generations. Over recent years, there h...
Mammalian germ cells are powerful cells, the only ones that transmit information to the next generat...
In the human embryo, the genetic program that orchestrates germ cell specification in-volves the act...
In the human embryo, the genetic program that orchestrates germ cell specification involves the acti...
In the human embryo, the genetic program that orchestrates germ cell specification in-volves the act...
The founder cells of the gametes are primordial germ cells (PGCs). In mammals, PGCs are specified ea...
SummarySpecification of primordial germ cells (PGCs) marks the beginning of the totipotent state. Ho...
Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, ...
Human germ cell development is regulated in a spatio-temporal manner by complex regulatory network...
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation hu...
Primordial germ cells (PGC) are the precursor of the gametes, which safeguard the transmission of ge...
In most multicellular organisms, including mammals, germ cells are at the origin of new organisms an...
SummaryWe recently elucidated the mechanism of human primordial germ cell (hPGC) specification and r...
Primordial germ cells (PGCs) have long been considered the link between one generation and the next....
Development of a malignant germ cell tumor, i.e., germ cell cancer (GCC) in individuals with disorde...
Germline stem cells are key to genome transmission to future generations. Over recent years, there h...
Mammalian germ cells are powerful cells, the only ones that transmit information to the next generat...