This paper introduces a conceptual 100BillionTransistor (100BT) SuperComputers-on-a-Chip consisting of N big multi-core processors, 1000N small many-core processors, and two hardware accelerators - an ASIC TPU-like fixed-structure systolic array accelerator and a FPGA based flexible-structure re-programmable accelerator for bandwidth-bound and latency-critical Machine Learning applications respectively. The proposed SuperComputers-on-a-chip concept requires interfaces to specific external accelerators based on Quantum, Optical, Molecular, and Biological paradigms (programmable using EnergyFlow programming models - Energy Flow also representing a concept introduced in this paper) but these issues are outside the scope of this article. Keywor...