Cognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers.
- Watson, Andrew J
- Giordano, Annalisa
- Suckling, John
- Barnes, Thomas RE
- Husain, Nusrat
- Jones, Peter B
- Krynicki, Carl R
- Lawrie, Stephen M
- Lewis, Shôn
- Nikkheslat, Naghmeh
- Pariante, Carmine M
- Upthegrove, Rachel
- Deakin, Bill
- Dazzan, Paola
- Joyce, Eileen M
DOIAbstract
BACKGROUND: Evidence suggests that cognitive subtypes exist in schizophrenia that may reflect different neurobiological trajectories. We aimed to identify whether IQ-derived cognitive subtypes are present in early-phase schizophrenia-spectrum disorder and examine their relationship with brain structure and markers of neuroinflammation. METHOD: 161 patients with recent-onset schizophrenia spectrum disorder (<5 years) were recruited. Estimated premorbid and current IQ were calculated using the Wechsler Test of Adult Reading and a 4-subtest WAIS-III. Cognitive subtypes were identified with k-means clustering. Freesurfer was used to analyse 3.0 T MRI. Blood samples were analysed for hs-CRP, IL-1RA, IL-6 and TNF-α. RESULTS: Three subtypes were i...
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